Correlation between Helicobacter pylori infection and serum 25-hydroxyvitamin D 3 level in elderly physical examination population
10.3760/cma.j.cn115624-20241104-00878
- VernacularTitle:老年健康体检人群幽门螺杆菌感染与血清25羟维生素D 3水平的相关性
- Author:
Shanxiang LEI
1
;
Cong MA
;
Mengyu TAO
;
Guogang XU
Author Information
1. 解放军总医院第二医学中心健康医学科，国家老年疾病临床医学研究中心，北京 100853
- Publication Type:Journal Article
- Keywords:
Aged;
Helicobacter pylori;
Vitamin D deficiency;
Physical examination;
Correlation
- From:
Chinese Journal of Health Management
2025;19(4):306-311
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To discuss the correlation between Helicobacter pylori(Hp) infection and serum 25-hydroxyvitamin D3(25(OH)D 3)level in the elderly physical examination population. Methods:It was a cross-sectional study. Selecting individuals who met the inclusion and exclusion criteria as the subjects of the study and underwent health check-ups between January 2018 and December 2019 in the Second Medical Center of Chinese PLA General Hospital.According to the Delta Over Baseline (DOB) value of 13C urea breath test, the subjects were divided into two groups: those with DOB value≥4 ( n=1 018) were diagnosed as Hp-positive and were included in the positive group, and the others were Hp-negative and were included in the negative group (DOB value<4, n=2 067). The age, gender, height, weight, disease history, family disease history and other basic medical records were recorded; and blood samples were drawn for analysis of blood test, blood biochemical test etc. Then the serum 25(OH)D 3 levels were compared between the two groups. The influencing factors of Hp infection were analyzed using a multifactor logistic regression model and the confounding factors were also adjusted. Results:A total of 3 085 elderly people (male 1 838, female 1 247) were selected in this study, the median age is 64 years, the detection rate of Hp was 33%. Single factor analysis showed that the serum 25(OH)D 3 level in the positive group was significantly lower than that in the negative group (20.59 ng/ml vs 21.07 ng/ml, P=0.012). Binary logistic regression analysis showed that the serum 25(OH)D 3 level was a negative influence factor on Hp infection( OR=0.984, P=0.008). High level of serum 25(OH)D 3 can reduce the risk of Hp infection ( OR=0.707, P=0.002). The three constructed Hp infection risk prediction models still showed statistically significant after controlling for confounding factors. Conclusion:The study shows a correlation between serum 25(OH)D 3 level and the Hp infection in the elderly people, and low level of serum 25(OH)D 3 is an independent risk factor for Hp infection in the elderly population.
