Physical examination population lifestyle pattern mining and association analysis with metabolic associated fatty liver disease
10.3760/cma.j.cn115624-20241204-00989
- VernacularTitle:体检人群生活方式模式挖掘及其与代谢相关脂肪性肝病的关联分析
- Author:
Xinyun TAN
1
;
Qingnan HE
;
Jiangang WANG
;
Bingqian ZHOU
;
Xinjuan HUANG
;
Manjie GUO
;
Huihui ZOU
;
Lei ZHAO
;
Chunxiang QIN
Author Information
1. 中南大学湘雅三医院健康管理中心，长沙 410013
- Publication Type:Journal Article
- Keywords:
Fatty liver;
Metabolism;
Lifestyle;
Lifestyle pattern;
Physical examination;
Cluster analysis
- From:
Chinese Journal of Health Management
2025;19(3):176-183
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the lifestyle pattern of the physical examination population and analyze its association with metabolic associated fatty liver disease (MAFLD).Methods:This was a cross-sectional study. Based on the data of 196 515 physical examination individuals from the Health Management Center of the Third Xiangya Hospital of Central South University from January 2016 to December 2020, the subjects were grouped and characterized by principal component analysis and cluster analysis. Among them, 137 277 cases with MAFLD diagnosis information were included in the association analysis between lifestyle pattern and MAFLD. The differences in lifestyle pattern choice among different age, sex, education level, marital status, occupational category and medical insurance type and their differences with the risk of MAFLD were analyzed. The generalized linear mixed model was used to control confounding factors and then association analysis was conducted.Results:There were 6 types of lifestyle patterns in the physical examination population, which were respectively: indulgent type-both physical and mental damage, remedial type-excessive diet, giving type-unique intensity, comfortable type-natural health, heavy smoking type-sedentary injury, heavy drinking type-attempting to make up, accounting for 7.29%, 9.62%, 7.43%, 52.16%, 9.77%, 13.73% in the population. Among them, the male lifestyle pattern was mainly the indulgent type, the remedial type, the heavy smoking type and the heavy drinking type, showing the characteristics of unhealthy lifestyle pattern; Women tended to have healthier lifestyle patterns. After association analysis with MAFLD, it was found that the prevalence of MAFLD was more than 50% in the people who belonged to the indulgent type, remedial type, the heavy smoking type and the heavy drinking type (53.62%, 57.06%, 51.25% and 50.50%, respectively), and the prevalence of MAFLD in the giving type group was 40.17%. The risk of MAFLD in comfortable group was relatively low (28.25%), and the difference in risk of MAFLD among all modes was statistically significant after controlling for confounding factors ( P<0.001). Conclusion:According to cluster mining, there are 6 types of lifestyle patterns in the physical examination population, and the healthier lifestyle pattern has a lower risk of MAFLD.
