Association between cardiometabolic multimorbidity and mild cognitive impairment among older adults in urban communities
10.3760/cma.j.issn.0254-9026.2025.12.020
- VernacularTitle:城市社区老年人心脏代谢性共病与轻度认知障碍的关联性研究
- Author:
Bingyu ZHANG
1
;
Jingjing ZHANG
;
Cheng CAI
;
Juan ZHOU
;
Jing LIU
;
Xiaoyu LOU
;
Yan ZENG
;
Guirong CHENG
;
Dan LIU
Author Information
1. 武汉科技大学医学院，武汉 430065
- Publication Type:Journal Article
- Keywords:
Cardiometabolic diseases;
Mild cognitive impairment;
Hubei Memory and Aging Cohort Study
- From:
Chinese Journal of Geriatrics
2025;44(12):1757-1765
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the association between cardiometabolic multimorbidity(CMM), the number of cardiometabolic diseases(CMD)and mild cognitive impairment(MCI)among the older adults in urban communities.Methods:Based on the baseline data of the Hubei Memory and Aging Cohort Study(HMACS)from 2018 to 2023, CMM was defined as the coexistence of two or more CMDs(Type 2 diabetes, stroke and ischemic heart disease). Multivariate logistic regression was employed to examine the association between CMM, the number of CMDs and the prevalence of MCI, as well as subgroup heterogeneity.Results:This study included 6 113 urban participants aged ≥65 years(55.6% were female; mean age 71.9±5.7 years). The prevalence of MCI was 19.3%, with an increasing trend observed as the number of CMD increased(17.7%, 20.5%, 24.6%, 28.3%). After adjusting for all variables, a significant association was observed between CMM group and the prevalence of MCI( OR: 1.24, 95% CI: 1.01-1.52)compared with the non-CMM group.As the number of CMD increased, the prevalence of MCI increased( Ptrend=0.011), but the association was only significant in the group with two CMDs.Subgroup analyses revealed that in males( OR: 1.48, 95% CI: 1.10-2.00), those with more than 9 years of education( OR: 1.52, 95% CI: 1.15-2.02), and those with hypertension( OR: 1.33, 95% CI: 1.05-1.67), CMM was significantly associated with MCI, and the association with MCI increased significantly with the increase in the number of CMDs(all Pfor trend <0.05). Conclusions:Among urban community-dwelling older adults aged ≥65 years in China, CMM and the cumulative number of CMDs are significantly associated with an increase of MCI, particularly in males, those with higher education levels, and those with hypertension.In the future, the need for enhanced MCI screening for CMM patients should be strengthened, and targeted prevention and control of cognitive impairment should be implemented for high-risk populations.
