Analysis of gait and eye movement characterization in early Parkinson's disease patients with sleep disorders
10.3760/cma.j.issn.0254-9026.2025.12.011
- VernacularTitle:早期帕金森病伴有睡眠障碍患者的步态与眼动特征分析
- Author:
Miaoxian XIE
1
;
Huijing LIU
;
Yueying LIU
;
Huimin CHEN
;
Zhengting LIN
;
Huanchang XU
;
Wen SU
Author Information
1. 北京医院神经内科 国家老年医学中心 中国医学科学院老年医学研究院 北京大学第五临床医学院，北京 100730
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
Sleep disorder;
Eye movements;
Gait
- From:
Chinese Journal of Geriatrics
2025;44(12):1690-1697
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the gait and eye movement parameters in early Parkinson's disease(PD)with sleep disorders, and analyze their association with underlying pathophysiological mechanisms.Methods:This study was a cross-sectional single-center design that included 82 early PD patients with Hoehn-Yahr(H-Y)staging ≤2.5 who visited Beijing Hospital from October 2023 to May 2025.Patients were divided into two groups according to the PDSS-2 score(total score ≤15 for the no sleep disorder group and total score >15 for the sleep disorder group). Gait and eye movement parameters were collected respectively through the ReadyGo system and the EyeKnow eye movement system, and analyzed in combination with clinical scales.Multivariate logistic regression was employed to identify independent characteristic parameters associated with sleep disorders.Results:In terms of gait, the sleep disorder group had significantly lower step speed, left-right stride speed, and left-right swing speed(all P<0.05), and significantly higher variability of left-right stride time( P=0.017, 0.026). Regarding eye movements, the sleep disorder group had significantly more vertical smooth pursuit offsets[(56.24±2.87)times vs.(45.98±18.18)times, P=0.040], significantly higher maximum real-time variability of the right eye in response to light stimuli(90.75 vs.67.95%, P=0.006), and a longer latency to error responses in the counter-scanning task(337.06 vs.286.63 ms, P=0.005). To precisely control for confounding factors, key covariates such as mood and disease severity were included in the multivariate logistic regression model.After comprehensive adjustment, higher anxiety levels(Hamilton Anxiety Rating Scale, HAMA)( OR=1.32, P<0.001)and an increased number of vertical smooth pursuit offsets( OR=1.06, P=0.010)were independent factors associated with sleep disorders in early PD patients. Conclusions:In early PD patients, sleep disorders are closely associated with specific abnormalities in gait and eye movement parameters.In particular, vertical smooth pursuit offsets may serve as an objective biomarker independent of emotional status, reflecting the dysfunction of shared neural circuits.However, further mechanism studies are needed to verify whether they reflect the dysfunction of shared neural circuits.
