The interaction between skeletal aging and systemic aging
10.3760/cma.j.issn.0254-9026.2025.10.004
- VernacularTitle:骨骼衰老与系统衰老的相互作用
- Author:
Zhenxing WANG
1
;
Xiangfeng YANG
;
Yanwei TONG
;
Yubo WANG
;
Zhuojun DUAN
;
Guoqing YIN
;
Hui XIE
Author Information
1. 中南大学湘雅医院骨科，长沙 410008
- Publication Type:Journal Article
- Keywords:
Skeleton;
Systems biology;
Communication;
Signal transduction
- From:
Chinese Journal of Geriatrics
2025;44(10):1340-1348
- CountryChina
- Language:Chinese
-
Abstract:
The interaction between skeletal aging and systemic aging has emerged as a frontier in the field of aging biology research.Recent studies have indicated that bones serve not only as mechanical support organs but also as endocrine organs that regulate systemic homeostasis through bone-derived factors.This review systematically elaborates the characteristics and mechanisms of skeletal aging, including tissue structural remodeling, cellular phenotypic changes, microenvironmental disruption, and molecular network disorders, etc.In aging organisms, bones interact with other organs to form a "bone-system aging axis", thereby promoting the occurrence and development of geriatric comorbidities.Accordingly, multi-target intervention strategies targeting the "bone-system aging axis" show the potential in decelerating the progression of systemic aging.In-depth research on the characteristic changes in inter-organ communication during the aging process of the body is not only conducive to facilitating the development of more comprehensive systemic anti-aging strategies, but also provides a new perspective for treating geriatric comorbidities and achieving healthy aging.
