Research Progress on Iron Overload and Pancreatic β-Cell Dysfunction
10.3760/cma.j.issn.0254-9026.2025.04.005
- VernacularTitle:铁过载与胰岛β细胞功能障碍的研究进展
- Author:
Yanyan WU
1
;
Mei HUANG
1
;
Wencan JIANG
1
;
Mei ZHANG
1
Author Information
1. 南京医科大学第一附属医院内分泌科，南京 210029
- Publication Type:Journal Article
- Keywords:
Iron overload;
Pancreatic β-cell dysfunction;
Type 2 diabetes mellitus
- From:
Chinese Journal of Geriatrics
2025;44(4):429-434
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic β-cell dysfunction is a critical factor in the pathogenesis of type 2 diabetes mellitus(T2DM).Recent studies have identified iron overload as a significant risk factor for T2DM, wherein excess iron contributes to β-cell dysfunction through multiple pathways, including oxidative stress, mitochondrial dysfunction, and a reduction in the number of pancreatic β-cells.These mechanisms adversely affect insulin synthesis, secretion, and release.This review aims to summarize the recent advancements in understanding the relationship between iron overload and pancreatic β-cell dysfunction.
