Research progress of receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB/osteoprotegerin signaling pathway in muscle diseases
10.3760/cma.j.issn.0254-9026.2025.08.024
- VernacularTitle:细胞核因子κB受体活化因子及其配体和骨保护素信号通路在肌肉疾病中的研究进展
- Author:
Lixun YANG
1
;
Yongxiang WANG
1
Author Information
1. 江苏省苏北人民医院 扬州市骨科重点实验室，扬州 225000
- Publication Type:Journal Article
- Keywords:
RANKL/RANK/OPG signal pathway;
Muscle
- From:
Chinese Journal of Geriatrics
2025;44(8):1170-1175
- CountryChina
- Language:Chinese
-
Abstract:
The receptor activator of nuclear factor-κB ligand(RANKL)/receptor activator of nuclear factor-κB(RANK)/osteoprotegerin(OPG)pathway is a key mechanism involved in senile osteoporosis.It interacts with various signaling pathways, musculoskeletal factors, and immune components, thereby influencing the integrity of the musculoskeletal system.Recent research has highlighted the significant role of this pathway in aging-related diseases, including sarcopenia, coronary artery disease, and heart failure.Furthermore, the interaction between muscle and bone is particularly critical in these conditions.This article reviewed the progress in research regarding the role of the RANKL/RANK/OPG signaling pathway in muscle-related diseases.
