Investigation of reference values for high-sensitivity cardiac troponin T in middle-aged and elderly populations by GAMLSS: A cross-sectional study
10.3760/cma.j.issn.0254-9026.2025.02.008
- VernacularTitle:基于位置、尺度、形状的广义可加模型构建中老年人高敏心肌肌钙蛋白T参考值
- Author:
Qian ZHANG
1
;
Weiyan ZHOU
;
Huiyi CHEN
;
Meng WANG
;
Wensong LIU
;
Lijuan WANG
;
Jiaqi ZHANG
;
Chuanbao LI
Author Information
1. 北京医院检验科 国家老年医学中心，中国医学科学院老年医学研究院，北京 100730
- Publication Type:Journal Article
- Keywords:
High-sensitivity cardiac troponin T;
Reference value;
Middle-aged and elderly;
Generalized additive model for location, scale and shape
- From:
Chinese Journal of Geriatrics
2025;44(2):156-161
- CountryChina
- Language:Chinese
-
Abstract:
Objective:to investigate age-related changes in high-sensitivity cardiac troponin T(hs-cTnT)levels among middle-aged and elderly individuals, and to establish reference values for the 99th percentile upper reference limit(99th URL)of hs-cTnT within this demographic.Methods:This research is designed as a cross-sectional study.Hs-cTnT test results were collected from outpatients at Beijing Hospital between January 2018 and December 2023.The final sample included 5, 677 outpatients aged 45 to 85 years(65±10), all of whom were free from cardiovascular diseases and other chronic heart-related conditions.Multiple linear regression was utilized to assess the impact of gender and age group on hs-cTnT concentrations within the middle-aged and elderly populations.Furthermore, a generalized additive model for location, scale, and shape(GAMLSS)was employed to generate percentile curves of hs-cTnT by gender in this cohort, with the aim of determining the 99th URLs for both middle-aged and elderly individuals.Results:Multiple linear regression analyses indicated that both gender and age significantly influenced hs-cTnT levels in middle-aged and elderly populations( β60-69 years=1.399, β≥70 years=5.306, βgender=-2.650, all Pvalues<0.001).The hs-cTnT data for both males and females conformed to Box-Cox-Cole-Green(BCCG)distributions, with percentile curves fitted at the 25th, 50th, 75th, and 99th percentiles according to gender.The percentile values of hs-cTnT in both males and females demonstrated a progressive increase with advancing age.Notably, males exhibited higher 99th percentile values than females across all age groups. Conclusions:The GAMLSS approach is employed to establish continuous reference intervals for hs-cTnT in the middle-aged and elderly population.This effort aims to provide a theoretical foundation for reference values specific to this demographic in China and to offer guidance for clinical diagnosis and treatment.
