Research on the clinical and pathological characteristics of nontuberculous mycobacterial disease
10.3760/cma.j.cn112309-20240807-00299
- VernacularTitle:非结核分枝杆菌病的临床与病理特征研究
- Author:
Feicheng YANG
1
;
Yuzhong YANG
;
Yafu ZHOU
;
Xiaoying LIU
;
Qing HU
;
Penghui DAI
;
Yan ZHOU
Author Information
1. 湖南省人民医院（湖南师范大学附属第一医院）病理科，长沙 410005
- Publication Type:Journal Article
- Keywords:
Nontuberculous mycobacteria;
Mycobacterium tuberculosis complex;
Metagenomics next generation sequencing
- From:
Chinese Journal of Microbiology and Immunology
2025;45(8):664-670
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the epidemiological and clinical characteristics of patients with nontuberculous mycobacterial infections in Hunan Province using metagenomics next generation sequencing (mNGS) .Methods:Pathological data form 320 patients diagnosed with mycobacterial infections at the Department of Pathology of Hunan People′s Hospital from June 2019 to December 2023 were collected, including HE staining, acid-fast staring, and fungal fluorescence staining. mNGS was utilized for the classification of mycobacterial pathogens.Results:Among 320 patients with mycobacterial infections, 249 cases were positive for Mycobacterium tuberculosis and 71 cases were positive for nontuberculous mycobacteria. Thirteen genera of nontuberculous mycobacteria were identified from the mycobacterial samples, including Mycobacterium chelonae, Mycobacterium avium complex, Mycobacterium abscessus, Mycobacterium gordonae, Mycobacterium intracellulare, Mycobacterium xenopi, Mycobacterium kansasii, Mycobacterium paragordonae, Mycobacterium obuense, Mycobacterium marinum, Mycobacterium fortuitum, Mycobacterium smegmatis and Mycobacterium mageritense. Conclusions:Infections caused by nontuberculous mycobacteria are gradually increasing, transitioning from single-strain infections to multi-strain complex infections. The histopathological features of nontuberculous mycobacterial infections are difficult to distinguish form those of tuberculosis, posing significant challenges for clinical diagnosis and treatment.
