The role and mechanism of innate immune cells in Mycobacterium tuberculosis infection
10.3760/cma.j.cn112309-20240403-00115
- VernacularTitle:固有免疫细胞在结核分枝杆菌感染中的作用及机制
- Author:
Jiaojiao WEI
1
;
Yu PANG
;
Fuzhen ZHANG
;
Ling LI
Author Information
1. 广东医科大学公共卫生学院，东莞 523808
- Publication Type:Journal Article
- Keywords:
Tuberculosis;
Innate immunity;
Immune responses;
Immune escape
- From:
Chinese Journal of Microbiology and Immunology
2025;45(7):605-610
- CountryChina
- Language:Chinese
-
Abstract:
Tuberculosis is a infectious disease caused by Mycobacterium tuberculosis( Mtb), which seriously threatens human health. Innate immune cells can synergistically resist the invasion of Mtb by phagocytosing pathogens, releasing inflammatory cytokines, and activating other immune cells, playing a crucial role in the host′s defense against Mtb infection. A comprehensive and in-depth understanding of the role of innate immune cells in Mtb infection will help reveal the complexity of immune response and understand the mechanism of early elimination of Mtb and immune escape of Mtb, and provide new ideas and strategies for the prevention and treatment of tuberculosis. This article will provide an overview of the research progress on the mechanisms of several important innate immune cells, including macrophages, neutrophils, natural killer cells, dendritic cells, and constant natural killer T cells, in Mtb infection.
