Detection and interpretation of PD-L1 in urologic neoplasms

VernacularTitle:泌尿系统肿瘤PD-L1的检测与判读
Author: Miaozi GONG ¹ ; Huiying HE
Author Information

1. 香港大学深圳医院病理科，深圳　518053
Publication Type:Journal Article
Keywords: Urologic neoplasms; Immunohistochemistry; Programmed cell death ligand 1
From: Chinese Journal of Pathology 2025;54(1):11-15
CountryChina
Language:Chinese
Abstract: Immune checkpoint inhibitors targeting PD-1/PD-L1 are gradually being applied in the treatment of advanced urinary system tumors. Immunohistochemical analysis of PD-L1 expression is the most popular method for screening suitable patients for immunotherapy and predicting therapeutic efficacy. The current application status of PD-L1 detection for urinary system tumors (mainly urothelial carcinoma), methods of the different antibody tests and the precautions, challenges and solutions in the interpretation of immunostaining were summarized in this review.