Progress in the role of neutrophil extracellular traps in sepsis and organ dysfunction
10.3760/cma.j.cn112309-20231111-00130
- VernacularTitle:中性粒细胞胞外诱捕网在脓毒症及其器官功能障碍中的研究进展
- Author:
Lijing QIN
1
;
Zhihui CHANG
1
Author Information
1. 中国医科大学附属盛京医院放射科，沈阳 110004
- Publication Type:Journal Article
- Keywords:
Sepsis;
NETs;
Organ dysfunction
- From:
Chinese Journal of Microbiology and Immunology
2025;45(3):264-268
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is a clinical syndrome resulting from infection followed by inflammation and is one of the significant causes of mortality worldwide. The underlying reason is the host′s uncontrolled inflammatory response to an infection, which leads to multiple organ dysfunction. It not only aggravates the condition, but also leads to a poor prognosis. Neutrophils are involved in many physiological and pathological processes in the human body and are forerunners to reach the site of infection/inflammation for clearing the infection and resolute the inflammation during sepsis. In addition, under the stimulation of pathogens, neutrophils can release a special network structure containing a variety of protein components and DNA as the skeleton, which is named neutrophil extracellular traps (NETs). Although NETs can kill pathogens, excess NETs have a significant influence on the pathogenesis of sepsis-induced multiple organ damage, including lung, kidney, and liver damage. This review aims to introduce the role of NETs in sepsis and organ dysfunction, hoping to provide new ideas for the treatment of sepsis.
