Analysis of respiratory pathogenic microorganisms in plasma samples from healthy plasma donors in winter
10.3760/cma.j.cn112309-20240314-00089
- VernacularTitle:冬季健康献浆员血浆样本中呼吸道病原微生物分析
- Author:
Yue WANG
1
;
Li CHENG
;
Ying LIU
;
Qin GONG
;
Jianxiao TONG
;
Chuanbo ZHAO
;
Jiaru GUO
;
Yan LUO
;
Jin ZHANG
Author Information
1. 国药集团武汉生物制药有限公司质量检定部，武汉 430207
- Publication Type:Journal Article
- Keywords:
Pathogenic microorganism;
Virus infection;
Bacterial infection;
Plasma donor
- From:
Chinese Journal of Microbiology and Immunology
2025;45(2):141-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To perform routine plasma test, SARS-CoV-2 nucleic acid test, and respiratory pathogenic microorganism nucleic acid test on plasma samples collected from 1 040 healthy plasma donors in winter.Methods:Plasma samples were collected from 1 040 healthy plasma donors at Yunmeng Plasma Collection Station in the winter of 2020. Routine plasma test, HBV/HCV/HIV nucleic acid test, SARS-CoV-2 nucleic acid test, and 22 respiratory pathogenic microorganism nucleic acid test were performed to analyze the quality of blood plasmas.Results:All plasma samples were qualified in the routine tests, meeting the requirements of the Chinese Pharmacopoeia, and tested negative for SARS-CoV-2 nucleic acid. Respiratory pathogenic microorganism nucleic acids were detected in 29 samples with a positive rate of 2.79% (29/1 040). There were 21 cases of simple virus infections, including 17 cases of coronavirus subtype infection, three cases of parainfluenza virus type 2 infection, and one case of human bocavirus infection. Eight cases were mixed infections of viruses and bacteria, four of which were viral infection combined with Bordetella pertussis. The 29 positive samples were collected from people of different age groups, including two from 31-40 years old (1.96%, 2/102 ), three from 41-50 years old (1.59%, 3/189), five from 51-55 years old (1.94%, 5/257), and 19 from 56-60 years old (4.59%, 19/414). Samples from the people aged 56-60 years accounted for the most (39.81%, 414/1 040), as well as the infection rate in this age group. Conclusions:In autumn and winter, respiratory pathogenic microorganism nucleic acid test should be performed when collecting plasma samples from donors aged 56-60 years in addition to meeting the requirements of the Chinese Pharmacopoeia. It is also suggested to conduct respiratory pathogenic microorganism nucleic acid test on pooled plasma and blood products.
