Progress in soluble secreted form of hepatitis E virus ORF2 protein
10.3760/cma.j.cn112309-20240604-00193
- VernacularTitle:戊型肝炎病毒ORF2分泌型蛋白研究进展
- Author:
Yansheng GENG
1
;
Chenyan ZHAO
Author Information
1. 河北大学公共卫生学院，保定 071000
- Publication Type:Journal Article
- Keywords:
Hepatitis E virus;
Capsid protein;
Non-structural protein;
Secreted form of ORF2 protein;
Glycosylated ORF2 protein
- From:
Chinese Journal of Microbiology and Immunology
2025;45(2):149-155
- CountryChina
- Language:Chinese
-
Abstract:
The genome of hepatitis E virus (HEV) contains three open reading frames (ORF1-3), among which ORF2 encodes the viral capsid protein. It has been believed that ORF2 only encodes the structural protein for assembling the capsid of HEV virion. However, recent findings have revealed that during HEV replication, ORF2 also produces a substantial amount of glycosylated soluble protein secreted outside the host cells, known as the ORF2 secreted form (ORF2S). Although not involved in virion assembly, the soluble secreted form of ORF2 protein may play a crucial role in HEV infection and pathogenesis. This review presents an overview of research progress in HEV ORF2S.
