Comparative analysis of etiological characteristics of influenza-like illness and severe acute respiratory infection in Guangdong Province from August to December 2023
10.3760/cma.j.cn112309-20240428-00150
- VernacularTitle:广东省2023年8—12月流感样疾病病例和严重急性呼吸道感染病例病原体感染情况的对比分析
- Author:
Lei WANG
1
;
Jianxiang YU
;
Jiamin XIE
;
Huan ZHANG
;
Qianfang GUO
;
Haiyan WANG
;
Zhencui LI
;
Bosheng LI
;
Lirong ZOU
Author Information
1. 广东省疾病预防控制中心，广东省新发传染病应急检测技术研究与应用重点实验室，广州 511430
- Publication Type:Journal Article
- Keywords:
Respiratory tract infection;
Influenza-like illness;
Severe acute respiratory infection;
Multiple respiratory pathogen detection
- From:
Chinese Journal of Microbiology and Immunology
2025;45(1):26-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the etiological characteristics between influenza-like illness (ILI) cases in outpatient and emergency departments and those with severe acute respiratory infection (SARI) in Guangdong Province, hoping to provide scientific evidence for the treatment, prevention, and control of respiratory infectious diseases.Methods:Laboratory testing for multiple respiratory pathogens was conducted on 6 090 specimens collected from ILI and SARI cases in Guangdong Province from August to December 2023. Chi-square test was used to analyze the differences in positive rates. Results:The overall positive rate of respiratory pathogens was 49.5% (3 016/6 090). The positive rate was 54.5% (2 260/4 145) in ILI cases and 38.9% (756/1 945) in SARI cases. The overall positive rate was higher in ILI cases than in SARI cases across all genders and age groups, and in most cities of the province, with statistically significant differences ( P<0.05). No significant difference was found in the overall positive rate between different genders. However, the difference between different age groups was statistically significant( P<0.001), with the highest rate identified in children aged 5-14 years (57.2%, 957/1 673). The main pathogens detected in ILI cases were influenza virus, human rhinovirus/enterovirus, and Streptococcus pneumoniae, while in SARI cases they were Mycoplasma pneumoniae, human rhinovirus/enterovirus, and influenza virus. The positive rates of adenovirus, human parainfluenza virus, SARS-CoV-2, human coronavirus, influenza virus, and Streptococcus pneumoniae were significantly higher in ILI cases than in SARI cases, while the positive rate of Mycoplasma pneumoniae was significantly higher in SARI cases ( P<0.05). Moreover, ILI cases were characterized by a higher risk of coinfection compared with SARI cases, especially in males or those aged 25-59 years. Conclusions:There are differences in the detection rates and spectrum of respiratory pathogens between ILI and SARI cases in Guangdong Province. Case features should be considered when developing strategies for preventing and treating respiratory infections.
