Clinical characteristics and prognostic analysis of newly diagnosed acute myeloid leukemia with critical illness
10.3760/cma.j.cn121090-20241211-00561
- VernacularTitle:初诊危重急性髓系白血病的临床特征及预后分析
- Author:
Peiqi LIANG
1
;
Meng GAO
1
;
Yan XIE
1
;
Bingqing LI
1
;
Qian LI
1
;
Ziyi LIU
1
;
Dong WANG
1
;
Huiying QIU
1
;
Suning CHEN
1
;
Depei WU
1
;
Jianhong FU
1
Author Information
1. 国家血液系统疾病临床医学研究中心，苏州大学附属第一医院血液科重症监护病房，江苏省血液研究所，苏州 215006
- Publication Type:Journal Article
- Keywords:
Leukemia, myeloid, acute;
Intensive care unit;
Critical illness;
Early death
- From:
Chinese Journal of Hematology
2025;46(1):39-44
- CountryChina
- Language:Chinese
-
Abstract:
Objective:This study retrospectively analyzed the clinical characteristics of patients newly diagnosed with acute myeloid leukemia (AML) who were admitted to the hematology intensive care unit (HCU) with critical illness. It also examined factors associated with critical illness and early mortality in these patients.Methods:Clinical data were collected from 91 newly diagnosed AML patients admitted to the HCU of the Department of Hematology, First Affiliated Hospital of Soochow University, from October 2020 to 2024. Reasons for HCU admission, major therapeutic interventions, and risk factors for critical illness and early mortality were analyzed.Results:The median time from diagnosis to HCU admission was 3 days ( IQR: 3–9 days), and the median HCU stay was 10 days ( IQR: 3–23 days). Of the 91 patients, 71 were admitted to the HCU before induction chemotherapy, while 20 were transferred to the HCU after its initiation. The leading causes of HCU admission were pulmonary infection (78.0% ), respiratory failure (44.0% ), hepatic insufficiency (28.6% ), renal insufficiency (27.5% ), disseminated intravascular coagulation (DIC; 25.3% ), and sepsis (23.1% ). Median Acute Physiology and Chronic Health Evaluation Ⅱ (APACHE Ⅱ) and SOFA scores at HCU admission were 14 ( IQR: 11–18) and the median Sepsis Related Organ Failure Assessment (SOFA) score was 7 ( IQR: 4, 10). Major HCU interventions included vasoactive drugs, noninvasive and invasive mechanical ventilation, continuous renal replacement therapy, therapeutic leukocyte clearance, and cardiopulmonary resuscitation. Among patients receiving induction chemotherapy, the composite complete remission rate was 65.4%, and the overall remission rate was 88.5%. Thirty-five (38.5% ) patients died within 28 days of HCU admission. Independent risk factors for 28-day mortality were DIC ( OR=9.350, 95% CI 1.999–43.745, P=0.005), sepsis ( OR=6.817, 95% CI 1.571–29.582, P=0.010), and cardiac insufficiency ( OR=12.281, 95% CI 2.385–63.254, P=0.003) . Conclusion:The main reason for HCU admission in newly diagnosed critically ill AML patients was pulmonary infection. Nearly 40% of patients experisenced early death, and DIC, sepsis, and heart failure were factors influencing early mortatlity.
