Study on risk factors of sarcopenia in middle aged and elderly inpatients with type 2 diabetes mellitus
10.3760/cma.j.issn.0254-9026.2025.08.010
- VernacularTitle:中老年住院2型糖尿病患者肌少症危险因素的研究
- Author:
Jipeng ZHANG
1
;
Liru CHEN
;
Hong JIANG
Author Information
1. 中共中央办公厅警卫局卫生保健处，北京 100000
- Publication Type:Journal Article
- Keywords:
Type 2 Diabetes mellitus;
Hospitalization;
Sarcopenia;
Age;
Sex
- From:
Chinese Journal of Geriatrics
2025;44(8):1070-1077
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To explore the common risk factors of sarcopenia in middle-aged and elderly inpatients with type 2 diabetes mellitus(T2DM).Methods:A total of 1 125 middle-aged and elderly T2DM inpatients admitted to the Endocrinology Department of Beijing Hospital from January 2014 to December 2019 were selected and divided into three groups according to age: 50-<60 years old, 60-<75 years old, and ≥75 years old; According to the inclusion and exclusion criteria, 269 study subjects were divided into sarcopenia group( n=90)and non-sarcopenia group( n=179). General data of 1 125 subjects were collected and analyzed.With the presence or absence of sarcopenia as the dependent variable, multivariate logistic regression was used to analyze the relevant risk factors of sarcopenia in middle-aged and elderly inpatients with T2DM.With the comparison of the differences between the sarcopenia group and the non-sarcopenia group, stepwise regression analysis was used to explore the related factors of sarcopenia occurrence. Results:Among the 1 125 patients, the detection rate of muscle content reduction in male was 18.26%, which was significantly higher than that in female 9.28%( P<0.05). The detection rate of muscle content reduction in the senile group was higher than that in 50-<60 years old group and 60-<75 years old group( P<0.05). The proportion of patients with sarcopenia in ≥75 years old group was higher than that in 50-<60 years old group and 60-<75 years old group( P<0.05). The prevalence of sarcopenia in male and ≥75 years old groups was significantly higher than that in female in 50-<60 years old group and the senile group( P<0.05). Logistic regression analysis showed that T2DM patients aged ≥75( OR=4.992, 95% CI: 2.448-10.179)and with glycated hemoglobin(HbA1c)>10%( OR=3.563, 95% CI: 1.526-8.322)had a significantly increased risk of sarcopenia( P<0.05). The proportion of patients with ≥75 years, with a diatetes duration of ≥20 years, with hypertension, with coronary heart disease, with asthma, treated with dipeptidyl peptidase-4(DPP-4)inhibitors, with low albumin and with HbA1c<7% in the sarcopenia group was higher than that in the non-sarcopenia group( P<0.05). T2DM patients aged ≥75 years old( OR=12.140, 95% CI: 2.740-53.790), with a diabetes duration of ≥20 years( OR=3.270, 95% CI: 1.100-9.740), with asthma( OR=7.570, 95% CI: 1.270-45.150), no use of DPP-4 inhibitors( OR=1.950, 95% CI: 1.070-3.570), and with a 2-hour postpranpranal blood glucose ≥11.1mmol/L( OR=0.160, 95% CI: 0.060-0.420)had a significantly increased risk of sarcopenia.( P<0.05). Conclusions:Male and elderly inpatients with T2DM aged ≥ 75 years have a higher detection rate of muscle content reduction and sarcopenia.The main risk factors for sarcopenia in middle-aged and elderly inpatients with T2DM include age HbA 1C, diabetes duration, asthma, use of DPP-4 inhibitors and 2-hour postprandial blood glucose.
