Drug susceptibility and clinical data analysis of Cryptococcus neoformans from patients with acquired immunodeficiency syndrome in a hospital in Shanghai
10.3760/cma.j.cn112309-20240628-00236
- VernacularTitle:上海市某医院艾滋病患者新生隐球菌药物敏感性及临床资料分析
- Author:
Shuai PAN
1
;
Yan WANG
1
;
Yushuo CAO
1
;
Ao WU
1
;
Chunyi YANG
1
;
Wenqiong ZHANG
1
;
Zhaoqin ZHU
1
;
Jinfeng CAI
1
Author Information
1. 上海市公共卫生临床中心检验医学科，上海 201508
- Publication Type:Journal Article
- Keywords:
Acquired immunodeficiency syndrome;
Cryptococcus neoformans;
Drug susceptibility
- From:
Chinese Journal of Microbiology and Immunology
2025;45(6):467-471
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the clinical data, drug resistance and treatment prognosis of Cryptococcus neoformans isolated from patients with acquired immunodeficiency syndrome(AIDS) in a hospital in Shanghai. Methods:The clinical data of AIDS patients with Cryptococcus neoformans infection in Shanghai Public Health Clinical Center from January 2014 to December 2023, and the drug sensitivity to 5 antifungal drugs in vitro, treatment and prognosis were retrospectively analyzed. Results:From January 2014 to December 2023, there were 295 AIDS patients with Cryptococcus neoformans infection in our hospital, with 255 males and 40 females. CD4 + T lymphocyte counts ≤100 cells/μl were detected in 251 patients. A total of 384 strains of Cryptococcus neoformans were isolated from the 295 patients, with the highest detection rate in cerebrospinal fluid samples (65.9%, 253/384), followed by blood samples (29.4%, 113/384). The sensitivity of 384 strains of Cryptococcus neoformans to 5-fluorocytosine was the highest (98.5%, 379/384), followed by fluconazole (95.6%, 367/384) and amphotericin B (95.3%, 366/384). After treatment against cryptococcal infection, 252 patients (86.0%, 252/293) were discharged and 20 patients (6.8%, 20/293) died. The other 2 cases were not treated for cryptococcal infection. Conclusions:As Cryptococcus neoformans is an important pathogen of AIDS patients, clinicians should actively carry out laboratory examination of Cryptococcus and rational drug use according to the results of drug sensitivity test, while alert to the occurrence of drug resistance.
