Roles of Fibronectin extra domain B(FN-EDB)in tumor microenvironment and progress in targeted immunotherapy research
10.3969/j.issn.1000-484X.2025.07.016
- VernacularTitle:纤维连接蛋白额外结构域B(FN-EDB)在肿瘤微环境中的作用及其靶向免疫治疗研究进展
- Author:
Junyu CAI
1
;
Xia LI
;
Jiannan FENG
;
Hui LI
;
Jing WANG
Author Information
1. 河南大学抗体药物开发技术国家地方联合工程实验室,开封 475004
- Publication Type:Journal Article
- Keywords:
Tumor microenvironment;
Fibronectin extra domain B;
Extracellular matrix;
Targeted immunotherapy
- From:
Chinese Journal of Immunology
2025;41(7):1647-1655,1664
- CountryChina
- Language:Chinese
-
Abstract:
Intricate and complex interactions between tumor cells and tumor microenvironment(TME)are essential driving factors in tumor development and metastasis.In recent years,modulation of TME to reverse tumor progression has garnered significant attention as a therapeutic strategy.For precise and targeted tumor treatment,there is an urgent need for accurate and effective TME tar-get molecules and relevant prediction model.Fibronectin,a protein with multiple domains in extracellular matrix(ECM),plays a cru-cial role in physiological and pathological processes.Particularly,Fibronectin extra domain B(FN-EDB)in fibronectin is pivotal in regulating interaction between ECM and cells.During active tissue remodeling processes,especially in angiogenesis,FN-EDB expres-sion tends to increase.Studies have indicated that FN-EDB is involved in regulating various key aspects of tumorigenesis,including promoting tumor cell invasion and metastasis,influencing development of immune evasion mechanisms,enhancing tumor angiogene-sis,and contributing to development of chemoresistance.Therefore,targeting FN-EDB as a potential therapeutic target for cancer treat-ment and developing relevant therapeutic drugs hold significant importance and promising clinical prospects.This article reviews roles of FN-EDB in TME in recent years and research progress on tumor immunotherapy targeting this molecule,with aim of providing new insights and strategies for cancer treatment.
