Research progress on the dual role of tumor-associated neutrophil heterogeneity in tumor microenvironment
10.12354/j.issn.1000-8179.2025.20251150
- VernacularTitle:肿瘤相关中性粒细胞异质性在肿瘤微环境中的双重作用研究进展
- Author:
Li RONG
1
;
Li YIQING
1
;
Yan YAPING
1
;
Zhao DEHUA
1
;
Bu ZONGYAO
1
;
Ge XIAOJUN
1
Author Information
1. 遵义医科大学第二附属医院检验科(贵州省遵义市 563000)
- Publication Type:Journal Article
- Keywords:
tumor-associated neutrophils(TAN);
dual role;
immunotherapy;
tumor micoenvironment(TME);
heterogeneity
- From:
Chinese Journal of Clinical Oncology
2025;52(18):963-967
- CountryChina
- Language:Chinese
-
Abstract:
Tumor-associated neutrophils(TAN)are key components of the tumor microenvironment(TME)that exert dual regulatory roles in tumor progression through highly heterogeneous functional phenotypes.This review systematically addresses the dynamic balance of TAN in pro-tumor and anti-tumor mechanisms:TAN can directly kill tumor cells or collaborate with immune cells to activate anti-tumor re-sponses;however,in contrast,they can accelerate tumor progression by promoting angiogenesis,remodeling the extracellular matrix,and mediating immune evasion.Studies have shown that the functional heterogeneity of TAN is precisely regulated by multiple signaling net-works within the TME,and that the plasticity transformation of different subsets directly influences tumor progression.In-depth analyses of TAN subset characteristics,transformation mechanisms,and their clinical relevance will provide a theoretical basis for the development of inhibitors targeting pro-tumor neutrophils as well as advance the establishment of precise patient selection strategies for TAN subtype-based immunotherapy.
