Clinical characteristics of 57 AIDS patients complicated with cryptococcal meningitis,therapies and their therapeutic effects
10.11816/cn.ni.2025-242107
- VernacularTitle:57例AIDS合并隐球菌性脑膜炎临床特征及其疗法和疗效评估
- Author:
Manna ZHANG
1
;
Yi WAN
;
Xiaoyan YANG
;
Taihao CHEN
;
Lanxin HUANG
;
Xiaoxin XIE
;
Hai LONG
;
Junhua WANG
Author Information
1. 贵州医科大学公共卫生与健康学院环境污染与疾病监控教育部重点实验室,贵州安顺 561113;贵阳市公共卫生救治中心感染科,贵州贵阳 550001
- Publication Type:Journal Article
- Keywords:
Human immunodeficiency virus;
Cryptococcus;
Meningitis;
Clinical characteristic;
T lymphocyte sub-set;
Biochemical index
- From:
Chinese Journal of Nosocomiology
2025;35(21):3271-3275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To analyze the characteristics of 57 acquired immune deficiency syndrome(AIDS)patients complicated with cryptococcal meningitis and observe the treatment outcomes.METHODS Totally 57 AIDS pa-tients with complicated cryptococcal meningitis who were treated in Guiyang Public Health Treatment Center from Jan.2019 to Jun.2023 were continuously assigned as the cryptococcal meningitis group,meanwhile,57 patients with simple AIDS were chosen as the simple AIDS group based on a 1∶1 ratio matching case-control study.Both groups received standardized therapies on basis of the criteria.The clinical characteristics,T lymphocyte subsets,biochemical indexes and treatment outcomes were observed and compared between the two groups.RESULTS There were no significant differences in gastrointestinal reactions,fever and eye discomfort between the two groups;the incidence of neurological symptoms of the cryptococcal meningitis group was higher than that of the simple AIDS group(P＜0.05).There was significant difference in the peripheral blood T lymphocyte subsets be-tween the cryptococcal meningitis group and the simple AIDS group(P＜0.05).The levels of whole blood CD4+,CD4+/CD8+and CD8+of the cryptococcal meningitis group were lower than those of the simple AIDS group;the serum glucose(GLU)level of the cryptococcal meningitis group was lower than that of the simple AIDS group;the serum adenosine deaminase(ADA)level of the cryptococcal meningitis group was higher than that of the sim-ple AIDS group;the serum immunoglobulin A(IgA)level of the cryptococcal meningitis group was higher than that of the simple AIDS group(P＜0.05).There were no significant differences in the immunological failure,vir-ological failure and immunological failure plus virological failure between the two groups after the treatment for 6 months.CONCLUSIONS The incidence of neurological symptoms is higher among the patients with AIDS com-plicated with cryptococcal meningitis than among the patients with simple AIDS.The patients have poor treatment outcomes and more severe damage of T lymphocyte subset functions,and the levels of biochemical indexes vary a-mong the patients,which may provide bases for diagnosis of diseases and assessment of curative effect and prog-nosis.
