Research progress on the critical role of mitochondrial dysfunction in the pathogenesis of depression and the regulatory interventions of traditional Chinese medicine
10.3969/j.issn.1671-7856.2025.06.013
- VernacularTitle:线粒体功能异常在抑郁症发病机制中的重要作用及中药调控干预的研究进展
- Author:
Fangying LU
1
;
Chao LI
;
Shangshu ZHANG
;
Shuhe LI
;
Meng WANG
Author Information
1. 华北理工大学中医学院,河北唐山 063210
- Publication Type:Journal Article
- Keywords:
depression;
mitochondria;
traditional Chinese medicine;
pathogenesis;
treatment
- From:
Chinese Journal of Comparative Medicine
2025;35(6):119-128
- CountryChina
- Language:Chinese
-
Abstract:
Depression is a common mental disorder with adverse effects on human health and quality of life.Although its pathogenesis remains unclear,numerous recent studies have indicated a close association between depression and mitochondrial dysfunction.This review explores the critical role of mitochondrial dysfunction in the pathogenesis of depression from the aspects of energy metabolism disorders,oxidative stress and inflammatory responses,mitochondrial DNA damage and mutations,and the imbalance of the mitochondrial quality control systems.We also summarize recent advances in the use of traditional Chinese medicine(TCM)to treat depression by regulating mitochondrial function.The findings show the potential of TCM in enhancing mitochondrial energy metabolism,reducing oxidative stress and inflammatory responses,improving mitochondrial DNA,and modulating the mitochondrial quality control systems,including for the in-depth study of the pathogenesis of depression and its treatment with TCM.
