Association between clearance of serum procalcitonin and risk of 28-day in-hospital mortality of sepsis patients
10.11816/cn.ni.2025-250872
- VernacularTitle:脓毒症血清降钙素原清除与28 d院内死亡风险的相关性
- Author:
Ren JIANG
1
;
Zhaolan OUYANG
1
;
Siqi YI
1
Author Information
1. 中山大学附属第一医院惠亚医院重症医学科,广东惠州 516081
- Publication Type:Journal Article
- Keywords:
Sepsis;
Serum procalcitonin;
Serum procalcitonin clearance;
Risk of mortality;
Association
- From:
Chinese Journal of Nosocomiology
2025;35(21):3254-3259
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explorer the association between the clearance of serum procalcitonin(PCTc)and the risk of 28-day in-hospital mortality of the sepsis patients.METHODS A total of 270 patients who were diagnosed with sepsis in Huiya Hospital,the First Affiliated Hospital of Sun Yat-sen University from Jan.2022 to Jan.2025 were recruited as the research subjects and were divided into the low decline group with 76 cases,the moderate de-cline group with 74 cases and the high-level stability group with 120 cases according to the change of serum PCTc within 1 to 7 days after the admission.The association between the trajectory of change of PCTc and the risk of 28-day mortality of the sepsis patients was observed by Cox regression analysis method.The rough risk ratios(RRs)of complications of the different changing trajectories of PCTc were calculated by binary log-binomial regres-sion model.RESULTS The red blood cell(RBC)counts,white blood cell(WBC)counts,thrombin time(TT),prothrombin time(PT),activated partial thromboplastin time(APTT),D-dimer(D-D),C-reactive protein(CRP)and neutrophil to lymphocyte ratio(NLR)were higher in the low decline group than in the moderate de-cline and the high-level stability group(P＜0.05);while the levels of platelet(PLT)and fibrinogen(FIB)of the high-level stability group were higher than those of the low and moderate decline group(P＜0.05).Kaplan-meier survival curve analysis showed that the accumulative survival rate was 46.62％in the low decline group,64.31％in the moderate decline group and 81.24％in the high-level stability group,there was significant differ-ence(x2=25.479,P＜0.001).CONCLUSION The trajectory of change of PCTc can be served as an early-warn-ing index for the risk of in-hospital mortality and complications,which may provide important basis for develop-ment of individualized treatment program.
