Progress in role of traditional Chinese medicine regulating ferroptosis in hematological malignancies
10.3969/j.issn.1000-4718.2025.04.023
- VernacularTitle:中药调控铁死亡在血液系统恶性肿瘤中作用的研究进展
- Author:
Yuxin WEI
1
;
Jiongping HAN
;
Yifan YANG
;
Weiying FENG
Author Information
1. 绍兴文理学院医学院,浙江 绍兴 312000
- Publication Type:Journal Article
- Keywords:
ferroptosis;
hematologic tumors;
traditional Chinese medicine;
signaling pathways
- From:
Chinese Journal of Pathophysiology
2025;41(4):809-815
- CountryChina
- Language:Chinese
-
Abstract:
Hematologic malignancies arise from hematopoietic or immune system tissues and are characterized by abnormal cellular growth.Ferroptosis,a newly recognized form of cell death,is driven by mechanisms such as iron me-tabolism,oxidative defense,and lipid peroxidation.Increasing evidence has highlighted a significant link between ferrop-tosis and various hematologic cancers.Traditional Chinese medicine(TCM)has shown particular promise in the treatment of these cancers,offering unique therapeutic approaches.This article explores the role of ferroptosis modulation in hemato-logic malignancies and reviews the current understanding of how TCM's bioactive compounds and monomers exert their ef-fects in managing hematologic cancers,including leukemia,lymphoma,and multiple myeloma,through the induction of ferroptosis.The objective is to provide insight into potential strategies for targeting ferroptosis as a treatment approach for these malignancies.
