Exploration on the Role of Tumor Microenvironmental Disorders in Lung Cancer Metastasis Based on the Theory of"Kenang"
10.19879/j.cnki.1005-5304.202503593
- VernacularTitle:基于"窠囊"理论探讨肿瘤微环境紊乱在肺癌转移中的作用
- Author:
Yuchen GE
1
;
Zhe WANG
;
Yuhan WANG
;
Yunyun QUE
;
Jianhui JIANG
;
Tian TIAN
Author Information
1. 北京中医药大学中医学院,北京 100029
- Publication Type:Journal Article
- Keywords:
Kenang;
tumor microenvironment;
lung cancer;
metastasis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(12):25-29
- CountryChina
- Language:Chinese
-
Abstract:
Metastasis is one of the main causes of death in lung cancer,and tumor microenvironment(TME)disorders promote the formation of Kenang and accelerate lung cancer metastasis.The theory of"Kenang"in TCM is of great significance in explaining the pathogenesis of lung cancer metastasis and guiding clinical treatment.Based on the theory of"Kenang",this article discussed the pathogenesis and treatment of TME disorder in lung cancer metastasis,and analyzed the mechanism of Kenang in the process of lung cancer metastasis based on the pathological mechanism of Kenang formation and its similarity with TME disorder,combined with modern medical research results.The dynamic pathogenesis evolution of"healthy qi deficiency-phlegm-stasis-cancerous toxin"runs through the course of Kenang and lung cancer,and is closely related to the hypoxia,angiogenesis,and inflammatory microenvironment contained in TME disorders.Therefore,this article proposed a hypothesis that TME disorder may be the key to promote the formation of Kenang and accelerate the metastasis of lung cancer.The metastasis of lung cancer should be prevented and treated by the ideas of strengthening the healthy qi and promoting qi circulation,dissolving phlegm and removing stasis,clearing heat and detoxifying,so as to provide a theoretical for the prevention and treatment of lung cancer metastasis by integrated traditional Chinese and Western medicine.
