Predictive value of serum FOXO3 and TXNIP for major adverse cardiovascular event in elderly patients after PCI
10.12007/j.issn.0258-4646.2025.04.003
- VernacularTitle:血清FOXO3和TXNIP对老年PCI术后患者发生主要心血管不良事件的预测价值
- Author:
Lixin XIE
1
;
Guijiao LI
1
Author Information
1. 南宁市第三人民医院心内科二区,南宁 530003
- Publication Type:Journal Article
- Keywords:
forkhead box protein O3;
thioredoxin interacting protein;
coronary heart disease;
percutaneous coronary intervention
- From:
Journal of China Medical University
2025;54(4):301-305
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the predictive value of serum forkhead box protein O3(FOXO3)and thioredoxin interacting protein(TXNIP)for major adverse cardiovascular event(MACE)in elderly patients with coronary heart disease(CHD)following percutaneous coronary intervention(PCI).Methods In total,120 elderly patients with CHD who underwent successful PCI at our hospital between June 2021 and May 2023 were enrolled.After 12 months of follow-up(6 patients lost to follow-up),the patients were divided into the MACE group(n=40)and non-MACE group(n=74)based on whether they experienced MACE,such as recurrent angina pectoris,acute myocardial infarction,and severe arrhythmia.Enzyme-linked immunosorbent assay was used to detect FOXO3 and TXNIP levels in serum.The Pearson analysis was used to analyze the correlation between serum FOXO3 and TXNIP levels in patients with CHD.A receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum FOXO3 and TXNIP levels for MACE in patients with CHD after PCI.Logistic regression was used to analyze the factors affecting the occurrence of MACE in patients with CHD after PCI.Results The serum FOXO3 level in the MACE group was significantly lower than that in the non-MACE group,while TXNIP levels were significantly higher(P＜0.05).Pearson analysis revealed that serum FOXO3 and TXNIP levels in patients with CHD were negatively cor-related(r=-0.586,P＜0.001).Logistic regression analysis revealed that FOXO3 and TXNIP were factors influencing MACE in patients with CHD after PCI(P＜0.05).The combined prediction of serum FOXO3 and TXNIP for MACE in patients with CHD after PCI had higher area under the curve than using FOXO3 and TXNIP alone(Z=7.583,P＜0.001;Z=8.640,P＜0.001).Conclusion The elderly CHD patients with MACE after PCI showed low FOXO3 expression and high TXNIP expression,which have a clinical predictive value for MACE occurrence in patients with CHD after PCI.
