Clinical value of ultrasound and contrast enhanced ultrasound in the differential diagnosis of pancreatic neuroendocrine tumors and pancreatic ductal adenocarcinoma
10.12007/j.issn.0258-4646.2025.04.013
- VernacularTitle:超声及超声造影在鉴别胰腺神经内分泌瘤与胰腺导管腺癌中的临床价值
- Author:
Weijuan FAN
1
;
Xiaoqian DENG
;
Lichun ZHENG
;
Xiangliu OUYANG
Author Information
1. 唐山中心医院超声医学科,河北 唐山 063008
- Publication Type:Journal Article
- Keywords:
pancreatic neoplasm;
neuroendocrine tumor;
pancreatic ductal adenocarcinoma;
ultrasound;
contrast enhanced ultrasound
- From:
Journal of China Medical University
2025;54(4):359-363
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the value of ultrasound and contrast enhanced ultrasound(CEUS)in the differential diagnosis of pancreatic neuroendocrine tumor(PNET)and pancreatic ductal adenocarcinoma(PDAC).Methods A retrospective analysis was performed on the clinical data,ultrasound findings,and CEUS findings of 74 patients with PNET and their characteristic manifestations were analyzed and compared with those of 74 patients with PDAC.Data of the two groups were compared using the t-test and x 2 test,or Fisher's exact test.Results There were 18,26,and 30 patients with PNET lesions and 52,8,and 14 patients with PDAC located in the head,body,and tail of the pancreas,respectively.The patients with hypoechoic lesions,regular lesion morphology,clear boundaries,pancreatic duct dilatation or cutoff,and blood flow signal accounted for 86.49％,83.78％,78.38％,18.92％and 32.43％in the PNET group,respectively,whereas in the PDAC group,such patients accounted for 94.59％,29.73％,27.03％,75.68％and 21.62％,respec-tively.There was a significant intergroup differences in lesion location,morphology,boundaries and pancreatic duct dilatation or cutoff(x 2=31.862,x2=44.048,x 2=39.141,and x 2=47.815,respectively,P＜0.05),with no significant differences in hypoechoic and blood flow signal(x2=2.840 and x2=2.193,P＞0.05).Among the 52 patients with PNET,CEUS showed that 38 had hyperenhancement and 14 had iso-enhancement in the arterial phase,whereas 40 had iso-enhancement and 12 had hypoenhancement in the venous phase.CEUS was performed in 74 patients with PDAC;70 patients showed hypoenhancement in the arterial phase and 72 showed hypoenhancement in the venous phase.There were significant differences in the enhancement pattern in the arterial and venous phases between the two groups(x 2=56.582 and x 2=37.852,P＜0.05).Conclusion Ultrasound and CEUS revealed some characteristics of PNET that can be used for the differential diagnosis of PNET and PDAC,when combined with enhancement pattern.
