Correlation of platelet to albumin ratio with occurrence of cerebral infarction after left atrial appendage closure in patients with non-valvular atrial fibrillation
10.3969/j.issn.1009-0126.2025.11.010
- VernacularTitle:血小板与白蛋白比值与非瓣膜病心房颤动患者左心耳封堵术后发生脑梗死的相关性
- Author:
Qinyu SUN
1
;
Jiling YU
1
;
Yifan DENG
1
;
Gan CAO
1
;
Zhen FANG
1
;
Jun JI
1
;
Shenghu HE
1
;
Jing ZHANG
1
Author Information
1. 苏北人民医院(扬州大学附属苏北人民医院)心血管内科,江苏扬州 225001
- Publication Type:Journal Article
- Keywords:
atrial fibrillation;
atrial appendage;
cerebral infarction;
correlation of data;
platelet-to-albumin ratio
- From:
Chinese Journal of Geriatric Heart Brain and Vessel Diseases
2025;27(11):1489-1493
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between platelet-to-albumin ratio(PAR)and occurrence of cerebral infarction after left atrial appendage closure(LAAC)in patients with non-valvular atrial fibrillation(NVAF).Methods A retrospective study was conducted on 259 NVAF patients undergoing LAAC in our department between 2019 and 2023.According to occurrence of cerebral infarction after LAAC or not,they were divided into a control group(241 cases)and a study group(18 cases).Their general data were collected,and Cox proportional hazards regression model was used to identify the risk factors for cerebral infarction.ROC curve was plotted to assess the predictive value of PAR for cerebral infarction in NVAF patients after LAAC,and the AUC value was calculated.Kaplan-Meier survival curve was drawn to analyze the incidence of cerebral infarction after LAAC in NVAF patients with different PAR values.Results The study group had significantly advanced age,higher SBP at admission,increased WBC,neutrophil,monocyte and platelet counts,longer thrombin time,elevated international normalized ratio(INR)and high-sensitivity C-reactive protein(hs-CRP)level,and higher PAR than the control group(P＜0.05,P＜0.01).Multivariate Cox regression analysis showed that PAR(HR=2.286,95％CI:1.182-4.420,P＜0.05)was an independent risk factor for cerebral infarction in NVAF patients after LAAC.ROC curve indicated that the AUC value of PAR in predicting cerebral infarction after LAAC in NVAF patients was 0.721(95％CI:0.586-0.856,P＜0.01),with an optimal cut-off value of 4.137,a sensitivity of 66.39％,and a specificity of 77.78％.Kaplan-Meier survival curve revealed that the higher the PAR value was,the higher the risk of cerebral infarction was(P＜0.01).Conclusion PAR is significantly correlated with cerebral infarction in NVAF patients after LAAC.The higher the PAR,the higher the risk of cerebral infarction,demonstrating its predictive value and being worthy of clinical promotion.
