Research progress of role of Th17 cells on target organ pro-inflammatory effects and insulin resistance
10.3969/j.issn.1006-6187.2025.04.013
- VernacularTitle:辅助性T细胞17对胰岛素靶器官促炎作用和引发胰岛素抵抗机制的研究进展
- Author:
Changyan ZI
1
;
Lisha HE
Author Information
1. 611137 成都,四川泰康医院中医科
- Publication Type:Journal Article
- Keywords:
T helper 17 cells;
Insulin resistance;
Adipose tissue;
Liver;
Skeletal muscle
- From:
Chinese Journal of Diabetes
2025;33(4):307-313
- CountryChina
- Language:Chinese
-
Abstract:
Insulin resistance induced by chronic inflammation plays a key role in the progress of metabolic diseases,including obesity,type 2 diabetes and fatty liver disease.In recent years,the process of T helper 17(Th17)cells inducing insulin resistance during inflammation has attracted much attention.Th17 cells can induce inflammatory responses in different insulin target organs(adipose tissue,liver,skeletal muscle,heart and brain)through various pathways,leading to damage to the insulin signal transduction pathway and thus causing insulin resistance.
