Distribution and drug resistance of multidrug-resistant organisms in newborns in a three-A children's hospital from 2019 to 2023
10.11816/cn.ni.2025-246981
- VernacularTitle:2019-2023年某三甲儿童医院新生儿多重耐药菌分布及耐药性
- Author:
Hongyan WU
1
;
Chunai ZHANG
;
Jun WANG
;
Huiping LIU
;
Qin WANG
;
Ling ZHANG
;
Nan GAO
;
Xue LI
;
Liyuan FU
;
Yun YANG
;
Yanjie WANG
;
Huayu HAN
Author Information
1. 河南省儿童医院郑州儿童医院党委办公室,河南郑州 450018
- Publication Type:Journal Article
- Keywords:
Neonate;
Intensive care unit;
Multidrug-resistant bacteria;
Distribution of drug-resistant bacteria;
Drug resistance;
Children's hospital;
Carbapenem-resistant Klebsiella pneumoniae;
Methicillin-resistant Staphy-lococcus aureus
- From:
Chinese Journal of Nosocomiology
2025;35(16):2485-2489
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To investigate the distribution and drug resistance of multidrug-resistant bacteria in the neonatal intensive care unit of a three-A children's hospital in Henan Province,and to provide reference for ational drug use in clinical practice.METHODS Clinical specimens from hospitalized newborns in neonatal intensive care unit from a three-A children's hospital from Jan.1,2019 to Dec.31,2023 were subjected to etiological exam-ination and drug sensitivity test,and to analyze the distribution and drug resistance of multidrug-resistant bacteri-a in hospitalized newborns.RESULTS During the 5-year period,1139 strains of multidrug-resistant bacteria were i-solated,including 229 gram-positive bacteria(20.11％)and 910 gram-negative bacteria(79.89％).There were 92 strains of methicillin-resistant Staphylococcus aureus(MRSA)(accounting for 8.08％),57 strains(accounting for 5.00％)of methicillin-resistant coagulase-negative Staphylococcus epidermidis and 28 strains(accounting for 2.46％)of methicillin-resistant coagulase-negative human Staphylococcus.370 strains(accounting for 32.48)of carbapenem-resistant Klebsiella pneumoniae(CRKP),268 strains(accounting for 23.53％)of extenspectrum β-lactamase-producing Escherichia coli and 85 strains(accounting for 7.46％)of K.pneumoniae,there were 767 sputum specimens(67.34％),160 blood specimens from peripheral intravenous puncture and central venous cath-eterization(PICC)(14.05％),63 bronchoalveolar lavage fluid specimens(5.53％),29 secretion specimens(eye and wound secretions)(2.54％),and 120 other specimens(10.54％).K.pneumoniae and E.coli producing su-per-broad spectrum β-lactamase,CRKP and MRSA were the main drug-resistant bacteria.CONCLUSION The sit-uation of drug resistance in neonatal intensive care unit is serious,therefore monitoring bacterial resistance should be strengthened according to the clinical laboratory results,and antibiotics should be applied rationally.
