Influencing factors for the 28-day prognosis of children with Mycoplasma pneumoniae pneumonia
10.11816/cn.ni.2025-246941
- VernacularTitle:肺炎支原体肺炎患儿28天预后的影响因素
- Author:
Yuxiong LIU
1
;
Qiang CAI
;
Min SHEN
;
Guirong HU
;
Wei WANG
;
Guojun LI
Author Information
1. 宜宾市第二人民医院儿科,四川宜宾 644000
- Publication Type:Journal Article
- Keywords:
Mycoplasma pneumoniae pneumonia;
Interleukin-4;
Interferon γ;
Prognosis;
Influencing factor
- From:
Chinese Journal of Nosocomiology
2025;35(16):2481-2484
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To explore the relationship between peripheral blood interferon γ(IFN-γ)/interleukin-4(IL-4)and the short-term prognosis of children with Mycoplasma pneumoniae pneumonia(MPP),and to analyze the influencing factors for the short-term prognosis of children with MPP.METHODS A total of 170 children with MPP admitted to the hospital from Jan.2021 to Jan.2024 were selected(MPP group).Based on the condition 28 days after treatment,they were divided into a poor prognosis group(n=49)and a good prognosis group(n=121).Clinical data of the children were collected,and the levels of peripheral blood interleukin-4(IL-4)and inter-feron-γ(IFN-γ)were measured to calculate the IFN-γ/IL-4 ratio.Multivariate Logistic regression model was used to analyze the factors affecting the short-term prognosis of children with MPP.RESULTS In the poor prognosis group,the duration of antibiotic use,the proportion of pleural effusion,the proportion of extrapulmonary compli-cations,and the levels of peripheral blood IL-4 and IFN-γ were higher than those in the good prognosis group,while the IFN-γ/IL-4 ratio was lower than that in the good prognosis group(P＜0.05).Logistic regression re-sults showed that persistent fever,prolonged antibiotic use and the occurrence of extrapulmonary complications were risk factors for the short-term prognosis of children with MPP(P＜0.05),and a high IFN-γ/IL-4 ratio was a protective factor(P＜0.05).CONCLUSION Persistent fever,prolonged antibiotic use and extrapulmonary com-plications are risk factors for the short-term prognosis of children with MPP,and high IFN-γ/IL-4 values is a pro-tective factor.
