Advance of research and application of rapid detection technique for medicine susceptibility for clinical microorganism
10.3969/j.issn.1672-8270.2025.08.029
- VernacularTitle:临床微生物快速药物敏感性检测技术研究与应用进展
- Author:
Yuhong HUANG
1
;
Qinghua QIU
1
;
Qian LI
1
;
Xuemin GUO
1
Author Information
1. 梅州市人民医院临床检验中心 梅州 514000
- Publication Type:Journal Article
- Keywords:
Drug susceptibility testing;
Antimicrobial resistance(AMR);
Rapid detection;
Genotype;
Phenotype
- From:
China Medical Equipment
2025;22(8):160-165
- CountryChina
- Language:Chinese
-
Abstract:
Antimicrobial resistance(AMR)has been a difficult problem of globally public health that can threaten human health.If its spread could not be effectively curbed,it will lead to increasing limitation in the options of clinical treatment.In the increasingly complex environment of diagnosis and treatment of infectious diseases,it is particularly urgent to build a rapid,accurate and widely popularized diagnosis system for pathogen,which is the key prerequisite of realizing accurate assessment for susceptibility of antimicrobial drug.This article comprehensively reviewed the main rapid diagnostic techniques currently used in AMR monitoring and detecting for antimicrobial susceptibility on the basis of the above conditions.It not only provided a detailed analysis of molecular typing methods represented by gene sequencing and phenotype identification methods based on conventional culture,but also focused on a new joint diagnostic strategy that combined genomic information with functional verification.Through comparative study for various technical principles,operating procedures and clinical applicability,the purpose of this paper was to provide scientific basis for optimizing the rapid detection scheme of drug susceptibility in clinical microbiology laboratories,and promote a comprehensive improvement of the level of diagnosis and treatment for infectious diseases,and ultimately improve the multi-layered network system of prevention and control for nosocomial infection.
