Analysis of influencing factors of Parkinson's disease with on-off phenomenon
10.3969/j.issn.1004-1648.2025.02.009
- VernacularTitle:帕金森病伴开-关现象的影响因素分析
- Author:
Xuan XU
1
;
Xinning ZHANG
;
Kaige ZHANG
Author Information
1. 100078 北京中医药大学东方医院脑病一科
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
on-off phenomenon;
risk factors
- From:
Journal of Clinical Neurology
2025;38(2):104-108
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influencing factors of Parkinson's disease(PD)with on-off phenomenon.Methods From January 2021 to November 2023,129 patients with PD who were admitted to the first Department of Encephalopathy in Dongfang Hospital of Beijing University of Chinese Medicine were retrospectively selected.Clinical data of PD patients were collected,and the patients were divided into a group without on-off phenomenon(95 cases)and a group with on-off phenomenon(34 cases).Binary Logistic regression was used to analyze the influencing factors of PD patients with on-off phenomenon.Results Compared with patients without on-off phenomenon,patients with on-off phenomenon had a longer disease course,more movement phenotypes with abnormal posture and gait,a higher proportion of patients with abnormal movements,a higher equivalent dose of levodopa,and higher unified PD rating scale-Ⅱ,Pittsburgh sleep quality index and the Epworth sleeping scale(ESS)scores,the differences of which were statistically significant(all P＜0.05).Binary Logistic regression analysis showed that the motor phenotypes of postulatory gait abnormalities(OR=3.116,95％CI:1.052-9.230),dyskinesia(OR=11.175,95％CI:1.752-71.301),high ESS scores(OR=1.135,95％CI:1.029-1.251)were independent risk factors for on-off phenomenon in PD patients(all P＜0.05).Conclusion The on-off phenomenon in PD patients is the result of multiple factors,in which the movement phenotype of postural and gait abnormality,dyskinesia,and high ESS scores are independent risk factors for the on-off phenomenon in PD patients.
