Clinical and imaging features of myelin oligodendrocyte glycoprotein antibody associated encephalitis characterized by bilateral caudate nucleus lesions(report of one case)
10.3969/j.issn.1004-1648.2025.02.003
- VernacularTitle:以双侧尾状核病变为表现的髓鞘少突胶质细胞糖蛋白抗体相关性脑炎的临床及影像学特点(附1例报告)
- Author:
Jian DING
1
;
Jing JIN
;
Xuegan LIAN
Author Information
1. 213003 常州,苏州大学附属第三医院(常州市第一人民医院)神经内科
- Publication Type:Journal Article
- Keywords:
myelin oligodendrocyte glycoprotein antibody associated encephalitis;
imaging features;
prognosis
- From:
Journal of Clinical Neurology
2025;38(2):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical and imaging features of myelin oligodendrocyte glycoprotein(MOG)antibody associated encephalitis.Methods A case of MOG antibody associated encephalitis with bilateral caudate nucleus lesions as imaging manifestations was reported.Clinical data were summarised,diagnostic,differential diagnosis and therapeutic analyses were performed,and a review of relevant literature was conducted.Results The patient was a 31-year-old male with acute onset of illness,mainly presenting with headache,fever,increased CSF cells and proteins,serum anti-MOG antibody IgG positivity(1∶100),CSF anti-MOG antibody IgG positivity(1∶10),and abnormal signals of bilateral caudate nucleus head on cranial MRI.After hormonal shock treatment,the headache was relieved rapidly and the body temperature returned to normal.However,the CSF protein and serum MOG antibody titre were higher than before,and tolizumab was given.Conclusion MOG antibody-associated encephalitis has a variety of clinical and imaging manifestations,and this case is instructive for enriching its clinical features,imaging spectrum and exploring its treatment.
