Role of autophagy in pathogenesis of rheumatoid arthritis
10.3969/j.issn.1000-484X.2025.04.038
- VernacularTitle:自噬在类风湿关节炎发病机制中的作用
- Author:
Liping LI
1
;
Peizhe XIA
1
;
Changjuan SHEN
1
;
Xi XIE
1
Author Information
1. 中南大学湘雅二医院风湿免疫科,长沙 410011
- Publication Type:Journal Article
- Keywords:
Rheumatoid arthritis;
Autophagy;
Pathogenesis
- From:
Chinese Journal of Immunology
2025;41(4):1004-1009
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a systemic inflammatory disease characterized by erosive arthritis that can eventually lead to joint deformity and loss of function,which is unknown.Autophagy is a self-degradation process in which cells reuse internal proteins and organelles allowing organisms to withstand adverse situations such as starvation and infection,and eventually allowing cells to survive.In recent years,many studies have discovered that autophagy plays a role in the pathogenesis of RA,including the production of pannus,synovitis,bone degradation,and other critical pathological connections that influence RA progression and prog-nosis.This article examines the function of autophagy in the pathogenesis of RA,with the goal of generating new ideas for future RA treatment and drug development.
