Cross-sectional Study on TCM Syndromes of 800 Patients with Overlapping Gastrointestinal Symptoms of NERD and EPS Based on Factor Analysis and Clustering Analysis
10.19879/j.cnki.1005-5304.202503321
- VernacularTitle:基于因子分析和聚类分析的800例非糜烂性反流病与上腹痛综合征胃肠症状重叠患者中医证型横断面研究
- Author:
Mi LYU
1
;
Hui CHE
;
Bingduo ZHOU
;
Zhaoxia LIU
;
Xiaoling ZHOU
;
Xiaokang WANG
;
Yuxi WANG
;
Xiyun QIAO
;
Jingyi XIE
;
Fengyun WANG
Author Information
1. 中国中医科学院西苑医院,北京 100091
- Publication Type:Journal Article
- Keywords:
non-erosive reflux disease;
epigastric pain syndrome;
TCM syndromes;
factor analysis;
clustering analysis
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(9):141-148
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore TCM syndrome distribution law in patients with overlapping non-erosive reflux disease(NERD)and epigastric pain syndrome(EPS)gastrointestinal symptoms.Methods A multi-center,cross-sectional study was conducted to investigate the general information of 800 patients with overlapping NERD and EPS gastrointestinal symptoms in four hospitals,such as gender,age,body mass index(BMI)and four diagnostic information of TCM.Descriptive frequency analysis,factor analysis and clustering analysis were used to summarize the TCM syndrome types and distribution characteristics.Results The average age of 800 patients with overlapping NERD and EPS gastrointestinal symptoms was(44.50±14.43)years old,the average BMI was(23.17±4.80)kg/m2,and the male to female ratio was 3:5.Frequency of 95 TCM symptoms/signs≥20%.18 common factor variables were obtained based on factor analysis,and the cumulative contribution rate was 67.11%.The first three syndrome elements of disease location were liver,stomach and spleen,and the disease nature syndrome elements were qi stagnation,qi deficiency and yin deficiency.Based on the clustering analysis of 18 common factor variables,combined with expert discussion,four main TCM syndrome types were obtained,which were liver-stomach stagnation heat syndrome(213 cases,26.63%),spleen-stomach damp heat syndrome(209 cases,26.13%),spleen-stomach deficiency and cold qi stagnation syndrome(190 cases,23.75%)and qi-phlegm stagnation syndrome(188 cases,23.50%).There was no significant difference in the distribution of TCM syndrome types among patients with different genders,ages and BMI values(P>0.05).Patients with a course of disease≥2 years and those residing long-term north of the Qinling-Huaihe Line showed a significantly higher prevalence of spleen-stomach dampness-heat syndrome(P<0.05).Conclusion The syndrome elements of disease location of overlapping NERD and EPS gastrointestinal symptoms are mainly liver,stomach and spleen.The TCM syndrome types are liver-stomach stagnation heat syndrome,spleen-stomach damp heat syndrome,spleen-stomach deficiency cold qi stagnation syndrome and qi-phlegm stagnation syndrome.The course of disease and the regional differences between north and south may be the influencing factors of the distribution of syndrome types.
