Study on the Quality Evaluation of Shuanghuanglian Oral Liquid after Mutual Substitution of Honeysuckle and Wild Honeysuckle Based on Supramolecular"Imprinting Template"
10.19879/j.cnki.1005-5304.202504046
- VernacularTitle:基于超分子"印迹模板"对金银花和山银花互代的双黄连口服液质量评价研究
- Author:
Haiying LI
1
;
Wenjiao LI
;
Ru QIAO
;
Fan CHEN
;
Xiangting GAO
;
Xiao XUE
;
Linjuan LIU
;
Meifeng XIAO
;
Peng HE
;
Fuyuan HE
Author Information
1. 湖南中医药大学第一附属医院,湖南 长沙 410007
- Publication Type:Journal Article
- Keywords:
molecular connectivity index;
total quantum statistical moment;
imprinting template;
fingerprint;
Shuanghuanglian Oral Liquid;
honeysuckle;
wild honeysuckle
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2025;32(9):120-127
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the quality of Shuanghuanglian Oral Liquid after mutual substitution of honeysuckle and wild honeysuckle using total quantum statistical moment(TQSM)and molecular connectivity index(MCI).Methods UPLC fingerprint of Shuanghuanglian Oral Liquid(honeysuckle)and Shuanghuanglian oral liquid(wild honeysuckle)were established,the TQSM parameters and similarity of the fingerprint were calculated;by reviewing relevant literature,as well as the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform(TCMSP),chemical composition databases for Shuanghuanglian Oral Liquid(honeysuckle)and Shuanghuanglian Oral Liquid(wild honeysuckle)was established,all components were divided into different component groups,and MCI and its similarity were calculated.Results The number of chromatographic peaks and total zero order moment(AUCT)of 15 batches of Shuanghuanglian Oral Liquid(honeysuckle)were higher than those of Shuanghuanglian Oral Liquid(wild honeysuckle),but there was no significant difference in total first order moment(MRTT)and total second order moment(VRTT);the total quantum statistical moment similarity(TQSMS)between 15 batches of Shuanghuanglian Oral Liquid(honeysuckle)was 1.000 0-0.824 6,the TQSMS between 15 batches of Shuanghuanglian Oral Liquid(wild honeysuckle)was 1.000 0-0.659 0,and the TQSMS between 15 batches of Shuanghuanglian Oral Liquid(honeysuckle)and Shuanghuanglian Oral Liquid(wild honeysuckle)was 1.000 0-0.619 8.The MCI similarity of various components between Shuanghuanglian Oral Liquid(honeysuckle)and Shuanghuanglian Oral Liquid(wild honeysuckle)was 1.000 0-0.984 9,with an overall MCI similarity of 0.995 8.Conclusion There is no significant difference in the various components and overall"imprinting template"between Shuanghuanglian Oral Liquid(honeysuckle)and Shuanghuanglian Oral Liquid(wild honeysuckle).It is speculated that the substitution of honeysuckle and wild honeysuckle will not affect the pharmacological properties of Shuanghuanglian Oral Liquid,but there may be differences in the intensity of pharmacological effects,with Shuanghuanglian Oral Liquid(honeysuckle)being the most effective.
