Network meta-analysis of efficacy and safety of different induction regimens in treatment of AIDS complicated with cryptococcal meningitis
10.11816/cn.ni.2025-246908
- VernacularTitle:不同诱导方案治疗艾滋病合并隐球菌脑膜炎有效性和安全性的网状Meta分析
- Author:
Jiangju WAN
1
;
Na LI
;
Ting LEI
;
Ji LUO
;
Wei ZHANG
;
Huarong LI
Author Information
1. 大理大学药学院,云南 大理 671000
- Publication Type:Journal Article
- Keywords:
Induction period;
Amphotericin B;
Cryptococcal meningitis;
Efficacy;
Safety;
AIDS;
Meta-analysis
- From:
Chinese Journal of Nosocomiology
2025;35(15):2293-2299
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE To systematically evaluate the efficacy and safety of different induction regimens for AIDS complicated with cryptococcal meningitis.METHODS PubMed,Embase,Cochranre library,Web of science,CNKI,Wanfang,Weipu and other databases were systematically searched to collect randomized controlled trials related to the induction treatments of AIDS complicated with cryptococcal meningitis.The search was limited to Oct.2024.The Cochrane risk of bias evaluation system was used to evaluate the quality of the literature,and Stata 15.1 and Revman 5.3 software were used for network meta-analysis.RESULTS A total of 17 randomized controlled trials involving 3,281 patients were included.The result of network meta-analysis showed that the treatment regi-men with the lowest early mortality was the short-course of amphotericin B+fluconazole+flucytosine;the regi-men with the lowest late mortality was a single high-dose amphotericin B liposome;the regimen with the highest 14-day fungal clearance rate was amphotericin B+flucytosine;the regimen with the lowest incidence of grade 3+4 anemia was a single high-dose amphotericin B liposome;the regimen with the lowest incidence of grade 3+4 re-nal injury was amphotericin B liposome;the regimen with the lowest incidence of grade 3-4 hypokalemia was flu-conazole+flucytosine.CONCLUSION According to the comprehensive analysis of various indices,there is good efficacy and safety for the inclusion of short-course amphotericin B regimen and single high-dose amphotericin B li-posome as induction period therapy for AIDS complicated with cryptococcal meningitis.
