Expert consensus on liquid biopsy-based multi-cancer early detection(2025 edition)
10.3760/cma.j.cn112152-20250605-00257
- VernacularTitle:基于液体活检技术的多癌种联合筛查专家共识(2025版)
- Author:
Chen WANQING
1
;
Chen KEXIN
;
He YUTONG
;
Jia WEIHUA
;
Liu ZHIHUA
;
Ma HONGXIA
;
Miao XIAOPING
;
Pan KAIFENG
;
Wu CHEN
;
Xia CHANGFA
;
Xing JINLIANG
;
Xu YONGJIE
Author Information
1. 国家癌症中心,国家肿瘤临床医学研究中心,中国医学科学院北京协和医学院肿瘤医院癌症早诊早治办公室(北京市 100021)
- Collective Name:Working Group for the Development of Expert Consensus on Liquid Biopsy-based Multi-Cancer Early Detec-tion
- Publication Type:Journal Article
- Keywords:
neoplasms;
liquid biopsy;
multi-cancer early detection;
tumor biomarkers;
expert consensus
- From:
Chinese Journal of Clinical Oncology
2025;52(14):727-742
- CountryChina
- Language:Chinese
-
Abstract:
Cancer stands as a significant global public health challenge,and cancer screening serves as a pivotal strategy for reducing its mortality.Presently,only a limited number of cancer types have appropriate screening methods available.Traditional single-cancer screen-ing approaches are fraught with limitations,including invasiveness,low accuracy,and poor patient compliance.Multi-cancer early detection(MCED)leveraging liquid biopsy technology enables non-invasive and efficient early detection of multiple cancers by analyzing biomarkers such as cell-free DNA,cell-free RNA,proteins,and metabolites in blood and other bodily fluids.This innovative approach substantially broadens the spectrum of detectable cancers and enhances population coverage,showcasing immense potential for improving existing can-cer screening strategies.This expert consensus comprehensively reviews the progress of liquid biopsy-based MCED,biomarker selection and detection technologies,the criteria for cancer type selection,research design and clinical utility evaluation,as well as implementation path-ways.The overarching goal of this consensus is to offer scientific guidance for further research and the widespread adoption of MCED,thereby facilitating the continuous optimization of cancer screening strategies.
