Application and progress of nano-medicine mediated cuproptosis in the breast cancer treatment
10.11904/j.issn.1002-3070.2025.02.010
- VernacularTitle:纳米医学介导的铜死亡在乳腺癌治疗中的应用和进展
- Author:
Rui WANG
1
;
Deyuan MA
;
Wangqiang JIA
;
Quanlin GUAN
Author Information
1. 兰州大学第一临床医学院(兰州 730000)
- Publication Type:Journal Article
- Keywords:
Cuproptosis;
Breast cancer;
Nano-medicine;
Copper-based nano-medicine;
Drug resistance
- From:
Practical Oncology Journal
2025;39(2):144-150
- CountryChina
- Language:Chinese
-
Abstract:
Over the past decade,the new cases and deaths of breast cancer has rank first among malignant tumors in women,and its incidence is rising,with a younger age trend.Breast cancer demonstrates a high degree of heterogeneity and is prone to drug re-sistance to comprehensive treatment.As a newly discovered regulatory cell death form mediated by copper,cuproptosis is closely relat-ed to the occurrence and development of breast cancer.With the advancement of nano-medicine,metal-based drugs represented by copper can selectively deliver copper ions to tumor sites through the specific delivery system of nanomaterials.These metal drugs kill tumor cells by inducing copper overload,regulating the tumor microenvironment,and enhancing anti-tumor immune response.There-fore,copper-based drugs exhibit significant application potential in the treatment of breast cancer.This article reviews of the mecha-nism of cuproptosis in the occurrence and development of breast cancer and the application and progress of nanomedicine-mediated cuproptosis in the treatment of breast cancer.
