Risk factors and prognostic analysis of immune checkpoint inhibitor-related pneumonitis in patients with advanced lung cancer
10.3969/j.issn.1673-9701.2025.22.002
- VernacularTitle:晚期肺癌患者并发免疫检查点抑制剂相关肺炎的危险因素及预后分析
- Author:
Yilian QIU
1
;
Ping LIU
1
;
Yating MAO
1
;
Chuanhua XIE
1
;
Shoujun GUO
1
Author Information
1. 赣州市肿瘤医院胸部肿瘤内科,江西赣州 341000
- Publication Type:Journal Article
- Keywords:
Advanced lung cancer;
Immune checkpoint inhibitor-related pneumonitis;
Risk factor;
Prognosis
- From:
China Modern Doctor
2025;63(22):5-8
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the risk factors and prognosis of patients with advanced lung cancer complicated with immune checkpoint inhibitor-related pneumonitis(CIP).Methods A total of 220 patients with advanced lung cancer who were treated at Ganzhou Cancer Hospital from January 2022 to October 2024 were selected as the research subjects.The patients were divided into non-CIP group(n=179)and CIP group(n=41)based on whether they had concurrent CIP.Compare the clinical characteristics of two groups of patients and analyze the related influencing factors of patients with advanced lung cancer complicated with CIP.Results There were statistically significant differences in age,gender,underlying pulmonary diseases,smoking history,history of thoracic radiotherapy,treatment plans,serum albumin(Alb),platelet to lymphocyte ratio(PLR),neutrophil to lymphocyte ratio(NLR),and absolute lymphocyte count(ALC)between two groups of patients(P＜0.05).Multivariate Logistic regression analysis showed that age,underlying pulmonary diseases,treatment plan,Alb,PLR,NLR,and ALC were all influencing factors for patients with advanced lung cancer complicated with CIP(P＜0.05).The 90-day cumulative survival rate of patients in CIP group was significantly lower than that in non-CIP group(58.54％ vs.77.09％,x2=5.918,P=0.015).With the increase of CIP classification,the 90-day cumulative survival rate of patients showed a downward trend(P＜0.05).Conclusion The incidence of CIP in patients with advanced lung cancer is relatively high.Age,underlying pulmonary diseases,treatment plan,and levels of Alb,PLR,NLR,and ALC are all influencing factors.CIP can have adverse effects on the prognosis of patients.
