Clinical characteristics and prognostic analysis of elderly patients with acute myeloid leukemia
10.3969/j.issn.1673-9701.2025.22.001
- VernacularTitle:老年急性髓系白血病的临床特点及预后分析
- Author:
Gang ZHANG
1
;
Xiaohui GAO
;
Shuping MO
;
Yan ZHOU
;
Mengjie WU
;
Haibing WU
;
Xiaoyan ZHAO
;
Minchao YAN
;
Yuan LI
;
Hui ZENG
Author Information
1. 嘉兴大学附属医院(嘉兴市第一医院)血液科 浙江嘉兴 314000
- Publication Type:Journal Article
- Keywords:
Elderly;
Acute myeloid leukemia;
Prognosis
- From:
China Modern Doctor
2025;63(22):1-4
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinical characteristics and prognostic risk factors in elderly patients with acute myeloid leukemia(AML).Methods A retrospective analysis was conducted on the clinical data of 101 elderly AML patients admitted to Affiliated Hospital of Jiaxing University from January 2022 to December 2024.All patients were treated with azacitidine+venetoclax regimen.The clinical characteristics of patients and the risk factors related to prognosis were explored.Results The median follow-up was 14 months.Among the 101 patients,74 achieved complete remission or complete remission with incomplete hematological recovery.The median overall survival(OS)of patients with aged ≥70 years,white blood cell count＞50 × 109/L,TP53 mutation,complex chromosomes,and high-risk European leukemia net(ELN)risk stratification was significantly shortened(P＜0.05).Multivariate analysis showed that age(HR=0.125,95％CI:0.023-0.662,P=0.015),white blood cell count(HR=0.145,95％CI:0.032-0.662,P=0.013),and ELN risk stratification(HR=100.397,95％CI:14.395-700.207,P＜0.001)were all independent influencing factors for OS in elderly AML patients.Conclusion Age,white blood cell count and ELN risk stratification are all independent influencing factors affecting OS in elderly AML patients.
