A Retrospective Cohort Study on the Correlation Between Helicobacter pylori Infection and Recurrence After Colorectal Adenoma Resection
10.3969/j.issn.1009-6604.2025.08.002
- VernacularTitle:幽门螺杆菌感染与结直肠腺瘤切除术后复发相关性的回顾性队列研究
- Author:
Zhihao YIN
1
;
Lingmei MENG
1
;
Yan XUE
1
;
Zhiqiang SONG
1
;
Liya ZHOU
1
Author Information
1. 北京大学第三医院消化科 幽门螺杆菌感染及上胃肠疾病防治研究北京市重点实验室,北京 100191
- Publication Type:Journal Article
- Keywords:
Helicobacter pylori;
Colorectal adenoma;
Polypectomy;
Recurrence;
Prognosis factor
- From:
Chinese Journal of Minimally Invasive Surgery
2025;25(8):457-463
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of Helicobacter pylori(H.pylori)infection on colorectal adenoma(CRA)recurrence after polypectomy and to study other potential prognosis factors associated with CRA recurrence.Methods This single-centered retrospective cohort study included 808 patients with CRA who underwent colonoscopy,polypectomy,and gastroscopy between January 2005 and October 2022.The patients were classified into three groups based on H.pylori infection status:persistently negative(group A,n=626),initially positive but turned negative(group B,n=141),and persistently positive(group C,n=41).The CRA recurrence and high-risk CRA or colorectal cancer(CRC)occurrence were assessed,and potential prognosis factors for recurrence were analyzed.Results During a median follow-up period of 1.6(1.1,2.4)years,the recurrence rate was 56.4%(456/808),including 124 cases(15.3%)of high-risk CRA/CRC[of which 5 cases(0.6%)were CRC]and 332 cases(41.1%)of low-risk CRA.The recurrence rates in the three groups were 55.4%(347/626),60.3%(85/141),and 58.5%(24/41),respectively,with no statistically significant difference(log-rank χ2=0.525,P=0.769).The high-risk CRA/CRC recurrence rates in the three groups were 14.9%(93/626),17.7%(25/141),and 14.6%(6/41),respectively,showing no significant intergroup differences(log-rank χ2=0.340,P=0.844).Multivariate analysis identified increasing age(HR=1.011,95%CI:1.002-1.021,P=0.020)and baseline high-risk CRA(HR=1.428,95%CI:1.183-1.724,P<0.001)as independent prognosis factors for CRA recurrence.Conclusions This study did not find a significant correlation between H.pylori infection and CRA recurrence after polypectomy.Increasing age and baseline high-risk CRA are prognosis factors for CRA recurrence.
