The role and research progress of miRNA in intestinal mucosal barrier function
10.3969/j.issn.1006-5725.2025.07.022
- VernacularTitle:miRNA在肠黏膜屏障功能中的作用研究进展
- Author:
Bangrong XU
1
;
Zhen-ghua JIANG
1
;
Xin CHEN
1
;
Jun CHEN
1
;
Haibo LUO
1
;
Daoming LIANG
1
Author Information
1. 昆明医科大学第二附属医院胃肠外科(云南 昆明 650101)
- Publication Type:Journal Article
- Keywords:
miRNA;
intestinal mucosal barrier;
IECs
- From:
The Journal of Practical Medicine
2025;41(7):1079-1083
- CountryChina
- Language:Chinese
-
Abstract:
The intestinal mucosal barrier plays a pivotal role in both innate and adaptive immune regulation.Its integrity is essential for maintaining overall health,as it acts as a critical interface between the luminal contents and the host immune system.MicroRNAs(miRNAs),which are small noncoding RNAs,function as potent genetic regulators by interacting with multiple target genes to modulate entire cellular pathways.Recent studies have demon-strated that miRNAs are intricately involved in regulating the function of the intestinal mucosal barrier.This review examines the role of miRNAs in the intestinal mucosal barrier,encompassing their mechanisms,relevant clinical research findings,and potential directions for future investigation,to elucidate the potential value of miRNAs in the pathogenesis,diagnosis,and treatment of related diseases.
