Clinical effects of Jinhua Qinggan Granules combined with azithromycin on patients with Mycoplasma pneumoniae pneumonia
10.3969/j.issn.1001-1528.2025.08.014
- VernacularTitle:金花清感颗粒联合阿奇霉素对肺炎支原体肺炎患者的临床疗效
- Author:
Qi-rui FAN
1
;
Bao-fang ZHANG
;
Wei GUO
;
Hong-bo WU
Author Information
1. 济南市第二妇幼保健院儿童保健部,山东济南 271100
- Publication Type:Journal Article
- Keywords:
Jinhua Qinggan Granules;
azithromycin;
Mycoplasma pneumoniae pneumonia;
NLRP3
- From:
Chinese Traditional Patent Medicine
2025;47(8):2577-2581
- CountryChina
- Language:Chinese
-
Abstract:
AIM To investigate the clinical effects of Jinhua Qinggan Granules combined with azithromycin on patients with Mycoplasma pneumoniae pneumonia.METHODS One hundred and three patients were randomly assigned into control group(51 cases)for 1-week intervention of both azithromycin and conventional treatment,and observation group(52 cases)for 1-wee intervention of Jinhua Qinggan Granules,azithromycin and conventional treatment.The changes in clinical effects,remission time for local symptoms(cough,wheezing,fever,pulmonary wet rales),pulmonary function indices(PEF,FEV1,FEV1/FVC),immune function indices(CD4+,CD8+,CD4+/CD8+),NLRP3 inflammatory pathway factors(Caspase-1,IL-1β,IL-18)and incidence of adverse reactions were detected.RESULTS The observation group demonstrated higher total effective rate than the control group(P＜0.05),along with shorter remission time for local symptoms(P＜0.05).After the treatment,the two groups displayed increased pulmonary function indices,CD4+,CD4+/CD8+(P＜0.05),and decreased CD8+,NLRP3 inflammatory pathway factors(P＜0.05),especially for the observation group(P＜0.05).No significant difference in incidence of adverse reactions was found between the two groups(P＞0.05).CONCLUSION For the patients with Mycoplasma pneumoniae pneumonia,Jinhua Qinggan Granules combined with azithromycin can safely and effectively improve clinical symptoms,pulmonary functions and immune functions,whose mechanism may contribute to the regulation of NLRP3 inflammasome pathway expressions.
