Recent advances in ductular reaction in the context of primary sclerosing cholangitis:mechanistic insights and targeted therapy
10.3969/j.issn.1000-4718.2025.02.019
- VernacularTitle:胆管反应在原发性硬化性胆管炎进展中的作用及其靶向治疗现状
- Author:
Yiming CUI
1
;
Bo HU
;
Haoting LIN
;
Jiamin WANG
;
Jian HONG
;
Ping TAO
Author Information
1. 暨南大学基础医学与公共卫生学院病理生理学系,国家中医药管理局病理生理学重点实验室,广东 广州 510632
- Publication Type:Journal Article
- Keywords:
primary sclerosing cholangitis;
ductular reaction;
inflammation;
fibrosis
- From:
Chinese Journal of Pathophysiology
2025;41(2):369-375
- CountryChina
- Language:Chinese
-
Abstract:
Primary sclerosing cholangitis(PSC)is an autoimmune disease characterized by chronic inflamma-tion and progressive fibrosis that affects both intrahepatic and extrahepatic bile ducts.Despite ongoing research,the under-lying mechanisms of PSC pathogenesis remain incompletely understood.The ductular reaction is not only a key pathologi-cal feature of PSC but also serves as a driving force in its progression.This review examines the promoting effects of the ductular reaction on PSC advancement from multiple perspectives,including the proliferation of biliary epithelial cells,in-flammation,and fibrosis.By providing theoretical insights into the pathogenesis of PSC,this review aims to facilitate the identification of novel therapeutic strategies.
