Research Progress of Tumor Diagnosis and Treatment Technology Based on Molecular Probes
10.11735/j.issn.1004-0242.2025.09.A006
- VernacularTitle:基于分子探针的肿瘤诊疗技术研究进展
- Author:
Xinglong CHEN
1
;
Lemeng ZHANG
;
Tianli CHENG
;
Yuning LI
;
Yifan YANG
;
Shuhua TAN
Author Information
1. 湖南科技大学生命科学与健康学院,湖南湘潭 411201;中南大学湘雅医学院附属肿瘤医院/湖南省肿瘤医院,湖南长沙 410006
- Publication Type:Journal Article
- Keywords:
molecular probes;
tumor diagnosis and treatment;
in vivo imaging;
tumor biomarkers
- From:
China Cancer
2025;34(9):724-733
- CountryChina
- Language:Chinese
-
Abstract:
As one of the major diseases threatening human health,the early accurate diagnosis and localization of tumors are crucial for formulating effective treatment plans.In recent years,molecular probes(MPs)have made significant progress in the field of biological imaging.With advantages such as high sensitivity,high specificity,and non-invasiveness,they have become a research hotspot in the field of tumor diagnosis and treatment.This paper systematically reviews the applications of MPs in tumor diagnosis and treatment,covering their classifications(such as fluorescent,photoacoustic,chemiluminescent,bioluminescent,and multimodal probes),design strategies(including active/pas-sive targeting mechanisms and the synergistic construction of identification units,imaging units,signal conversion units and treatment units),as well as detection principles.It also focuses on elabo-rating the research progress of MPs based on enzymes,receptors,reactive substances,and tumor microenvironment.Meanwhile,this paper emphasizes the advantages of multifunctional integration and multimodal imaging,and analyzes the challenges faced by MPs in clinical translation(such as biocompatibility and optimization of supporting equipment).It aims to provide ideas for the develop-ment of high-performance MPs and promote the advancement of precise and personalized tumor di-agnosis and treatment.
