Advances in role of tissue-resident memory T cells in SARS-CoV-2 infec-tion
10.3969/j.issn.1000-4718.2025.00.004
- VernacularTitle:组织驻留记忆T细胞参与新型冠状病毒感染的研究进展
- Author:
Dandan SHI
1
;
Ran CHEN
;
Jinming YE
;
Chuwen WANG
;
Guoqing QIAN
Author Information
1. 宁波大学医学部,浙江 宁波 315211
- Publication Type:Journal Article
- Keywords:
tissue-resident memory T cell;
SARS-CoV-2;
post-COVID-19 syndrome;
immune
- From:
Chinese Journal of Pathophysiology
2025;41(2):362-368
- CountryChina
- Language:Chinese
-
Abstract:
Tissue resident memory T(TRM)cells are a class of memory T cells with long life span and non-lymphoid resident characteristics.TRM cells are the first line of defense against secondary infections in human.TRM cells can restrict the transmission of viruses as well as combat against viruses.Rapid evolution of severe acute respiratory syn-drome coronavirus 2(SARS-CoV-2)and post-COVID-19 syndrome could lead to a series of symptoms such as pulmonary fi-brosis,resulting in long-term fall in quality of life.Many studies focused on enhancing the ability to cope with the mutation of SARS-CoV-2 and reducing the incidence of post-COVID-19 syndrome.The relationship between TRM cells and SARS-CoV-2 infection or therapy still remain unknown.It is significant to investigate TRM cells divergence and functions for the development of vaccines.We review the functions and residence properties of TRM cells,as well as their roles in SARS-CoV-2 infection and post-COVID-19 syndrome.In this review,we are dedicated to deepen our understanding of the immune process in SARS-CoV-2 infection and provide a new prospect for the prevention and treatment of post-COVID-19 syndrome.
