Progress of research on drug targets for treatment of leishmaniasis
10.11816/cn.ni.2025-250281
- VernacularTitle:利什曼病治疗药物靶点研究进展
- Author:
Zhiqiang KANG
1
;
Xiaohui WO
1
;
Wei WEI
1
Author Information
1. 呼伦贝尔市疾病预防控制中心,内蒙古呼伦贝尔 021008
- Publication Type:Journal Article
- Keywords:
Leishmaniasis;
Treatment;
Target point;
Progress;
Review
- From:
Chinese Journal of Nosocomiology
2025;35(16):2551-2555
- CountryChina
- Language:Chinese
-
Abstract:
Leishmania is a protozoan parasite that causes leishmaniasis,a disease prevalent in tropical regions.Vis-ceral leishmaniasis,also known as kala-azar in Asian countries,and cutaneous leishmaniasis are distributed world-wide.Chemotherapy with sodium stibogluconate and amphotericin B has shown significant effects.However,cur-rent treatment methods for leishmaniasis have various defects,including multiple side effects,prolonged treat-ment duration,varying efficacy across different regions,and the emergence of drug resistance.To address this ur-gent need,it is imperative to identify safer and more effective alternative treatment methods and seek for appropri-ate pharmacological targets.This review discusses key metabolic pathways that represent potential pharmacologi-cal targets,as well as emerging therapeutic strategies for leishmaniasis.
