Chemical constituents from Vespa basalis and their anti-inflammatory activity
10.3969/j.issn.1001-1528.2025.08.017
- VernacularTitle:基胡蜂化学成分及其抗炎活性研究
- Author:
Hai-yang LIU
1
;
Yin-he YANG
1
;
Da-song YANG
1
Author Information
1. 大理大学药学院云南省昆虫生物医药研发重点实验室,云南大理 671000
- Publication Type:Journal Article
- Keywords:
Vespa basalis(Smith);
chemical constituents;
isolation and identification;
anti-inflammatory activity
- From:
Chinese Traditional Patent Medicine
2025;47(8):2593-2597
- CountryChina
- Language:Chinese
-
Abstract:
AIM To study the chemical constituents from Vespa basalis(Smith)and their anti-inflammatory activity.METHODS Sephadex LH-20 gel and silica gel column chromatography were used for separation and purification,then the structures of obtained compounds were identified by physicochemical properties and spectral data.The RAW264.7 cell model was utilized to assess its anti-inflammatory activity in vitro.RESULTS Eleven compounds were isolated and identified as pyrrole-2-carboxylic acid(1),3-indolecarboxylic acid(2),p-hydroxybenzoic acid(3),phenylacetic acid(4),5α,8α-epidioxy-cholest-6-en-3β-ol(5),(2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-7-(N-acetyl-2″-aminethylene)-1,4-benzodioxane(6),(2R,3S)-2-(3′,4′-dihydroxyphenyl)-3-acetylamino-6-(N-acetyl-2″-aminoethyl)-1,4-benzodioxane(7),N-acetyldopamine(8),p-hydroxyphenylacetic acid(9),(R)-N-[2-(3,4-dihydroxyphenyl)-2-methoxyethyl]acetamide(10),(±)-cryptamide A(11).Compounds 3,5-6 and 10 inhibited the release of nitric oxide(NO)from RAW264.7 cell in a dose-dependent manner.CONCLUSION Compounds 1,2,and 5 are isolated from insects for the first time,while 6,7,10,and 11 are first isolated from the insects of Vespa genus.Compounds 3,5,6 and 10 have anti-inflammatory activity.
